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10.1007/s00395-020-00836-6 http://scihub22266oqcxt.onion/10.1007/s00395-020-00836-6 33284387!7720787!33284387     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Basic+Res+Cardiol 2020 ; 115 (6): 77 Nephropedia Template TP {{tp|p=33284387|t=2020. Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology |pdf=|usr=}}{{33284387}} gab.com Text Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology JO: Basic Res Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=33284387 #FOAvip Resident cardiac macrophages (rcMacs) are integral components of the myocardium where they have key roles for tissue homeostasis and in response to inflammation, tissue injury and remodelling. In this review, we summarize the current knowledge and limitations associated with the rcMacs studies. We describe their specific role and contribution in various processes such as electrical conduction, efferocytosis, inflammation, tissue development, remodelling and regeneration in both the healthy and the disease state. We also outline research challenges and technical complications associated with rcMac research. Recent technological developments and contemporary immunological techniques are now offering new opportunities to investigate the separate contribution of rcMac in respect to recruited monocytes and other cardiac cells. Finally, we discuss new therapeutic strategies, such as drugs or non-coding RNAs, which can influence rcMac phenotype and their response to inflammation. These novel approaches will allow for a deeper understanding of this cardiac endogenous cell type and might lead to the development of more specific and effective therapeutic strategies to boost the heart's intrinsic reparative capacity. Twit Text FOAVip Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology ????Basic Res Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=33284387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33284387 #FOAvip English Wikipedia <ref>{{Cite pmid|33284387}}</ref> Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology #MMPMID33284387 Sansonetti M; Waleczek FJG; Jung M; Thum T; Perbellini F Basic Res Cardiol 2020[Dec]; 115 (6): 77 PMID33284387show ga Resident cardiac macrophages (rcMacs) are integral components of the myocardium where they have key roles for tissue homeostasis and in response to inflammation, tissue injury and remodelling. In this review, we summarize the current knowledge and limitations associated with the rcMacs studies. We describe their specific role and contribution in various processes such as electrical conduction, efferocytosis, inflammation, tissue development, remodelling and regeneration in both the healthy and the disease state. We also outline research challenges and technical complications associated with rcMac research. Recent technological developments and contemporary immunological techniques are now offering new opportunities to investigate the separate contribution of rcMac in respect to recruited monocytes and other cardiac cells. Finally, we discuss new therapeutic strategies, such as drugs or non-coding RNAs, which can influence rcMac phenotype and their response to inflammation. These novel approaches will allow for a deeper understanding of this cardiac endogenous cell type and might lead to the development of more specific and effective therapeutic strategies to boost the heart's intrinsic reparative capacity. |Animals[MESH] |Heart Diseases/immunology/*metabolism/pathology/physiopathology[MESH] |Humans[MESH] |Macrophages/immunology/*metabolism[MESH] |Myocardium/immunology/*metabolism/pathology[MESH] |Phagocytosis[MESH] |Phenotype[MESH] |Regeneration[MESH] |Signal Transduction[MESH] |Ventricular Function, Left[MESH]Resident cardiac macrophages: crucial modulators of cardiac (patho)phy(epmc).pdf DeepDyve Pubget Overpricing