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10.3389/fimmu.2020.606489 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.606489 33281831!7689341!33281831     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 606489 Nephropedia Template TP {{tp|p=33281831|t=2020. The Role of Structure in the Biology of Interferon Signaling |pdf=|usr=}}{{33281831}} gab.com Text The Role of Structure in the Biology of Interferon Signaling JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33281831 #FOAvip Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of an antiviral state at the cell, tissue, organ, and organismal level is performed by three distinct IFN families, designated as Type-I, Type-II, and Type-III IFNs. Overall, there are 21 human IFNs, (16 type-I, 12 IFNalphas, IFNbeta, IFN?, IFNkappa, and IFNomega; 1 type-II, IFNgamma; and 4 type-III, IFNlambda1, IFNlambda2, IFNlambda3, and IFNlambda4), that induce pleotropic cellular activities essential for innate and adaptive immune responses against virus and other pathogens. IFN signaling is initiated by binding to distinct heterodimeric receptor complexes. The three-dimensional structures of the type-I (IFNalpha/IFNAR1/IFNAR2), type-II (IFNgamma/IFNGR1/IFNGR2), and type-III (IFNlambda3/IFNlambdaR1/IL10R2) signaling complexes have been determined. Here, we highlight similar and unique features of the IFNs, their cell surface complexes and discuss their role in inducing downstream IFN signaling responses. Twit Text FOAVip The Role of Structure in the Biology of Interferon Signaling ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33281831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33281831 #FOAvip English Wikipedia <ref>{{Cite pmid|33281831}}</ref> The Role of Structure in the Biology of Interferon Signaling #MMPMID33281831 Walter MR Front Immunol 2020[]; 11 (ä): 606489 PMID33281831show ga Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of an antiviral state at the cell, tissue, organ, and organismal level is performed by three distinct IFN families, designated as Type-I, Type-II, and Type-III IFNs. Overall, there are 21 human IFNs, (16 type-I, 12 IFNalphas, IFNbeta, IFN?, IFNkappa, and IFNomega; 1 type-II, IFNgamma; and 4 type-III, IFNlambda1, IFNlambda2, IFNlambda3, and IFNlambda4), that induce pleotropic cellular activities essential for innate and adaptive immune responses against virus and other pathogens. IFN signaling is initiated by binding to distinct heterodimeric receptor complexes. The three-dimensional structures of the type-I (IFNalpha/IFNAR1/IFNAR2), type-II (IFNgamma/IFNGR1/IFNGR2), and type-III (IFNlambda3/IFNlambdaR1/IL10R2) signaling complexes have been determined. Here, we highlight similar and unique features of the IFNs, their cell surface complexes and discuss their role in inducing downstream IFN signaling responses. |*Signal Transduction[MESH] |Animals[MESH] |Humans[MESH] |Interferons/chemistry/*metabolism[MESH] |Ligands[MESH] |Mice[MESH] |Models, Molecular[MESH] |Protein Conformation[MESH] |Receptors, Interferon/chemistry/*metabolism[MESH] |Species Specificity[MESH]The Role of Structure in the Biology of Interferon Signaling (epmc).pdf DeepDyve Pubget Overpricing