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10.1016/j.ebiom.2020.103154 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2020.103154 33279860!7714658!33279860     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2021 ; 63 (ä): 103154 Nephropedia Template TP {{tp|p=33279860|t=2021. Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study |pdf=|usr=}}{{33279860}} gab.com Text Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=33279860 #FOAvip BACKGROUND: Early diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. The objective of the current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19. METHODS: In this prospective observational study, we used real-time, online, proton transfer reaction time-of-flight mass spectrometry to perform a metabolomic analysis of expired air from adults undergoing invasive mechanical ventilation in the intensive care unit due to severe COVID-19 or non-COVID-19 acute respiratory distress syndrome (ARDS). FINDINGS: Between March 25(th) and June 25(th), 2020, we included 40 patients with ARDS, of whom 28 had proven COVID-19. In a multivariate analysis, we identified a characteristic breathprint for COVID-19. We could differentiate between COVID-19 and non-COVID-19 ARDS with accuracy of 93% (sensitivity: 90%, specificity: 94%, area under the receiver operating characteristic curve: 0.94-0.98, after cross-validation). The four most prominent volatile compounds in COVID-19 patients were methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal. INTERPRETATION: The real-time, non-invasive detection of methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal in exhaled breath may identify ARDS patients with COVID-19. FUNDING: The study was funded by Agence Nationale de la Recherche (SoftwAiR, ANR-18-CE45-0017 and RHU4 RECORDS, Programme d'Investissements d'Avenir, ANR-18-RHUS-0004), Region Ile de France (SESAME 2016), and Fondation Foch. Twit Text FOAVip Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=33279860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33279860 #FOAvip English Wikipedia <ref>{{Cite pmid|33279860}}</ref> Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study #MMPMID33279860 Grassin-Delyle S; Roquencourt C; Moine P; Saffroy G; Carn S; Heming N; Fleuriet J; Salvator H; Naline E; Couderc LJ; Devillier P; Thevenot EA; Annane D EBioMedicine 2021[Jan]; 63 (ä): 103154 PMID33279860show ga BACKGROUND: Early diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. The objective of the current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19. METHODS: In this prospective observational study, we used real-time, online, proton transfer reaction time-of-flight mass spectrometry to perform a metabolomic analysis of expired air from adults undergoing invasive mechanical ventilation in the intensive care unit due to severe COVID-19 or non-COVID-19 acute respiratory distress syndrome (ARDS). FINDINGS: Between March 25(th) and June 25(th), 2020, we included 40 patients with ARDS, of whom 28 had proven COVID-19. In a multivariate analysis, we identified a characteristic breathprint for COVID-19. We could differentiate between COVID-19 and non-COVID-19 ARDS with accuracy of 93% (sensitivity: 90%, specificity: 94%, area under the receiver operating characteristic curve: 0.94-0.98, after cross-validation). The four most prominent volatile compounds in COVID-19 patients were methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal. INTERPRETATION: The real-time, non-invasive detection of methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal in exhaled breath may identify ARDS patients with COVID-19. FUNDING: The study was funded by Agence Nationale de la Recherche (SoftwAiR, ANR-18-CE45-0017 and RHU4 RECORDS, Programme d'Investissements d'Avenir, ANR-18-RHUS-0004), Region Ile de France (SESAME 2016), and Fondation Foch. |Aged[MESH] |Area Under Curve[MESH] |Breath Tests[MESH] |COVID-19/*pathology/virology[MESH] |Critical Illness[MESH] |Discriminant Analysis[MESH] |Female[MESH] |Humans[MESH] |Least-Squares Analysis[MESH] |Male[MESH] |Metabolomics/*methods[MESH] |Middle Aged[MESH] |Pilot Projects[MESH] |Principal Component Analysis[MESH] |Prospective Studies[MESH] |ROC Curve[MESH] |Respiration, Artificial[MESH] |Respiratory Distress Syndrome/pathology[MESH] |SARS-CoV-2/isolation & purification[MESH]Metabolomics of exhaled breath in critically ill COVID-19 patients: A (epmc).pdf DeepDyve Pubget Overpricing