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10.1016/j.cca.2020.11.019

http://scihub22266oqcxt.onion/10.1016/j.cca.2020.11.019
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33279501!7836550!33279501
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suck abstract from ncbi


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pmid33279501      Clin+Chim+Acta 2021 ; 512 (ä): 49-57
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  • A nomogram to early predict isolation length for non-severe COVID-19 patients based on laboratory investigation: A multicenter retrospective study in Zhejiang Province, China #MMPMID33279501
  • Xia Y; Zhang Y; Yuan S; Chen J; Zheng W; Xu X; Xie X; Zhang J
  • Clin Chim Acta 2021[Jan]; 512 (ä): 49-57 PMID33279501show ga
  • BACKGROUND: Majority coronavirus disease 2019 (COVID-19) patients are classified as mild and moderate (non-severe) diseases. We aim to develop a model to predict isolation length for non-severe patients. METHODS: Among 188 non-severe patients, 96 patients were enrolled as training cohort to identify factors associated with isolation length via Cox regression model and develop a nomogram. Other 92 patients formed as validation cohort to validate nomogram. Concordance index (C-index), area under the curve (AUC) and calibration curves were used to evaluated nomogram. RESULTS: Increasing absolute eosinophil count (AEC) after admission was correlated with shorter isolation length (P = 0.02). Baseline activated partial thromboplastin time (APTT) > 30 s was correlated with longer isolation length (P = 0.03). A nomogram to predict isolation probability at 11-, 16- and 21-day was developed and validated. The C-indices of training and validation cohort were 0.604 and 0.682 respectively. Both cohorts showed a good discriminative ability (AUC, 11-day: 0.646 vs 0.730; 16-day: 0.663 vs 0.750; 21-day: 0.711 vs 0.783; respectively) and calibration power. CONCLUSIONS: Baseline APTT and dynamic change of AEC were two significant factors associated with isolation length of non-severe patients. Nomogram could predict isolation probability for each patient to estimate appropriate quarantine length.
  • |*Nomograms[MESH]
  • |*Physical Distancing[MESH]
  • |*Quarantine[MESH]
  • |Adult[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Area Under Curve[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19/blood/*etiology/*therapy[MESH]
  • |China[MESH]
  • |Eosinophils[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Leukocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Partial Thromboplastin Time[MESH]
  • |Proportional Hazards Models[MESH]
  • |Reproducibility of Results[MESH]
  • |Retrospective Studies[MESH]


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