Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1016/j.vetmic.2020.108933

http://scihub22266oqcxt.onion/10.1016/j.vetmic.2020.108933
suck pdf from google scholar
33278734!7685048!33278734
unlimited free pdf from europmc33278734    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid33278734      Vet+Microbiol 2021 ; 252 (ä): 108933
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • SARS-CoV-2 replicates in respiratory ex vivo organ cultures of domestic ruminant species #MMPMID33278734
  • Di Teodoro G; Valleriani F; Puglia I; Monaco F; Di Pancrazio C; Luciani M; Krasteva I; Petrini A; Marcacci M; D'Alterio N; Curini V; Iorio M; Migliorati G; Di Domenico M; Morelli D; Calistri P; Savini G; Decaro N; Holmes EC; Lorusso A
  • Vet Microbiol 2021[Jan]; 252 (ä): 108933 PMID33278734show ga
  • There is strong evidence that severe acute respiratory syndrome 2 virus (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, originated from an animal reservoir. However, the exact mechanisms of emergence, the host species involved, and the risk to domestic and agricultural animals are largely unknown. Some domestic animal species, including cats, ferrets, and minks, have been demonstrated to be susceptible to SARS-CoV-2 infection, while others, such as pigs and chickens, are not. Importantly, the susceptibility of ruminants to SARS-CoV-2 is unknown, even though they often live in close proximity to humans. We investigated the replication and tissue tropism of two different SARS-CoV-2 isolates in the respiratory tract of three farm animal species - cattle, sheep, and pigs - using respiratory ex vivo organ cultures (EVOCs). We demonstrate that the respiratory tissues of cattle and sheep, but not of pigs, sustain viral replication in vitro of both isolates and that SARS-CoV-2 is associated to ACE2-expressing cells of the respiratory tract of both ruminant species. Intriguingly, a SARS-CoV-2 isolate containing an amino acid substitution at site 614 of the spike protein (mutation D614G) replicated at higher magnitude in ex vivo tissues of both ruminant species, supporting previous results obtained using human cells. These results suggest that additional in vivo experiments involving several ruminant species are warranted to determine their potential role in the epidemiology of this virus.
  • |*Organ Culture Techniques[MESH]
  • |*Viral Tropism[MESH]
  • |*Virus Replication[MESH]
  • |Angiotensin-Converting Enzyme 2/genetics[MESH]
  • |Animals[MESH]
  • |Cattle/virology[MESH]
  • |Host Specificity[MESH]
  • |Respiratory System/*virology[MESH]
  • |Ruminants/*virology[MESH]
  • |SARS-CoV-2/genetics/*physiology[MESH]
  • |Sheep/virology[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box