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10.1182/bloodadvances.2020003170

http://scihub22266oqcxt.onion/10.1182/bloodadvances.2020003170
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33278301!7724912!33278301
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suck abstract from ncbi


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pmid33278301      Blood+Adv 2020 ; 4 (23): 5966-5975
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  • Outcomes of patients with hematologic malignancies and COVID-19: a report from the ASH Research Collaborative Data Hub #MMPMID33278301
  • Wood WA; Neuberg DS; Thompson JC; Tallman MS; Sekeres MA; Sehn LH; Anderson KC; Goldberg AD; Pennell NA; Niemeyer CM; Tucker E; Hewitt K; Plovnick RM; Hicks LK
  • Blood Adv 2020[Dec]; 4 (23): 5966-5975 PMID33278301show ga
  • Coronavirus disease 2019 (COVID-19) is an illness resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in late 2019. Patients with cancer, and especially those with hematologic malignancies, may be at especially high risk of adverse outcomes, including mortality resulting from COVID-19 infection. The ASH Research Collaborative COVID-19 Registry for Hematology was developed to study features and outcomes of COVID-19 infection in patients with underlying blood disorders, such as hematologic malignancies. At the time of this report, data from 250 patients with blood cancers from 74 sites around the world had been entered into the registry. The most commonly represented malignancies were acute leukemia (33%), non-Hodgkin lymphoma (27%), and myeloma or amyloidosis (16%). Patients presented with a myriad of symptoms, most frequently fever (73%), cough (67%), dyspnea (50%), and fatigue (40%). Use of COVID-19-directed therapies, such as hydroxychloroquine (n = 76) or azithromycin (n = 59), was common. Overall mortality was 28%. Patients with a physician-estimated prognosis from the underlying hematologic malignancy of <12 months at the time of COVID-19 diagnosis and those with relapsed/refractory disease experienced a higher proportion of moderate/severe COVID-19 disease and death. In some instances, death occurred after a decision was made to forgo intensive care unit admission in favor of a palliative approach. Taken together, these data support the emerging consensus that patients with hematologic malignancies experience significant morbidity and mortality resulting from COVID-19 infection. Batch submissions from sites with high incidence of COVID-19 infection are planned to support future analyses.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Azithromycin/therapeutic use[MESH]
  • |COVID-19/complications/mortality/virology[MESH]
  • |Female[MESH]
  • |Hematologic Neoplasms/complications/*pathology[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prognosis[MESH]
  • |Registries[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Severity of Illness Index[MESH]
  • |Survival Rate[MESH]
  • |Treatment Outcome[MESH]


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