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10.1038/s41576-020-00297-6 http://scihub22266oqcxt.onion/10.1038/s41576-020-00297-6 33277640!7716795!33277640     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33277640&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Genet 2021 ; 22 (3): 137-153 Nephropedia Template TP {{tp|p=33277640|t=2021. Host genetics and infectious disease: new tools, insights and translational opportunities |pdf=|usr=}}{{33277640}} gab.com Text Host genetics and infectious disease: new tools, insights and translational opportunities JO: Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=33277640 #FOAvip Understanding how human genetics influence infectious disease susceptibility offers the opportunity for new insights into pathogenesis, potential drug targets, risk stratification, response to therapy and vaccination. As new infectious diseases continue to emerge, together with growing levels of antimicrobial resistance and an increasing awareness of substantial differences between populations in genetic associations, the need for such work is expanding. In this Review, we illustrate how our understanding of the host-pathogen relationship is advancing through holistic approaches, describing current strategies to investigate the role of host genetic variation in established and emerging infections, including COVID-19, the need for wider application to diverse global populations mirroring the burden of disease, the impact of pathogen and vector genetic diversity and a broad array of immune and inflammation phenotypes that can be mapped as traits in health and disease. Insights from study of inborn errors of immunity and multi-omics profiling together with developments in analytical methods are further advancing our knowledge of this important area. Twit Text FOAVip Host genetics and infectious disease: new tools, insights and translational opportunities ????Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=33277640 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33277640 #FOAvip English Wikipedia <ref>{{Cite pmid|33277640}}</ref> Host genetics and infectious disease: new tools, insights and translational opportunities #MMPMID33277640 Kwok AJ; Mentzer A; Knight JC Nat Rev Genet 2021[Mar]; 22 (3): 137-153 PMID33277640show ga Understanding how human genetics influence infectious disease susceptibility offers the opportunity for new insights into pathogenesis, potential drug targets, risk stratification, response to therapy and vaccination. As new infectious diseases continue to emerge, together with growing levels of antimicrobial resistance and an increasing awareness of substantial differences between populations in genetic associations, the need for such work is expanding. In this Review, we illustrate how our understanding of the host-pathogen relationship is advancing through holistic approaches, describing current strategies to investigate the role of host genetic variation in established and emerging infections, including COVID-19, the need for wider application to diverse global populations mirroring the burden of disease, the impact of pathogen and vector genetic diversity and a broad array of immune and inflammation phenotypes that can be mapped as traits in health and disease. Insights from study of inborn errors of immunity and multi-omics profiling together with developments in analytical methods are further advancing our knowledge of this important area. |*Genetic Predisposition to Disease[MESH] |*Genetic Variation[MESH] |*Host-Pathogen Interactions[MESH] |COVID-19/*genetics/metabolism[MESH] |Humans[MESH]Host genetics and infectious disease: new tools, insights and translat(epmc).pdf DeepDyve Pubget Overpricing