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10.1038/s41598-020-78039-1

http://scihub22266oqcxt.onion/10.1038/s41598-020-78039-1
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33277573!7718220!33277573
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suck abstract from ncbi


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pmid33277573      Sci+Rep 2020 ; 10 (1): 21291
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  • Viral clearance after early corticosteroid treatment in patients with moderate or severe covid-19 #MMPMID33277573
  • Spagnuolo V; Guffanti M; Galli L; Poli A; Querini PR; Ripa M; Clementi M; Scarpellini P; Lazzarin A; Tresoldi M; Dagna L; Zangrillo A; Ciceri F; Castagna A
  • Sci Rep 2020[Dec]; 10 (1): 21291 PMID33277573show ga
  • The aim of this study was to evaluate the impact of early treatment with corticosteroids on SARS-CoV-2 clearance in hospitalized COVID-19 patients. Retrospective analysis on patients admitted to the San Raffaele Hospital (Milan, Italy) with moderate/severe COVID-19 and availability of at least two nasopharyngeal swabs. The primary outcome was the time to nasopharyngeal swab negativization. A multivariable Cox model was fitted to determine factors associated with nasopharyngeal swab negativization. Of 280 patients included, 59 (21.1%) patients were treated with steroids. Differences observed between steroid users and non-users included the proportion of patients with a baseline PaO(2)/FiO(2) 200 mmHg, and a lymphocyte count at admission > 1.0 x 10(9)/L. SARS-CoV-2 clearance was not associated with corticosteroid use. Our study shows that delayed SARS-CoV-2 clearance in moderate/severe COVID-19 is associated with older age and a more severe disease, but not with an early use of corticosteroids.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adrenal Cortex Hormones/*therapeutic use[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |COVID-19/epidemiology[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Retrospective Studies[MESH]
  • |Time Factors[MESH]
  • |Treatment Outcome[MESH]


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