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10.1016/j.mehy.2020.110434 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110434 33277106!7689313!33277106     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33277106&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Med+Hypotheses 2021 ; 146 (?): 110434 Nephropedia Template TP {{tp|p=33277106|t=2021. Can chloroquine/hydroxychloroquine prove efficient in cancer cachexia? A hypothesis in the era of COVID-19 |pdf=|usr=}}{{33277106}} gab.com Text Can chloroquine/hydroxychloroquine prove efficient in cancer cachexia A hypothesis in the era of COVID-19 JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33277106 #FOAvip Cancer cachexia (CC) is a progressive loss of muscle mass (with or without a decrease of adipose tissue). Gradual deterioration of the patient's fitness is resistant to nutritional intervention. The biochemical foundation of observed catabolism, detrimental protein, and energy balance is complex. However, the generalized inflammatory response plays a vital role. It is a kind of cytokine storm, which involves increased activity of TNF-alpha, IL-1, IL-6, and INF-gamma. Pharmacological treatment of cachexia consists mainly of progestagens and glucocorticosteroids. Still, the assessment of new options limiting the harmful impact of cachexia could be beneficial. Chloroquine (CQ) and hydroxychloroquine (HCQ) are old antimalarial agents endowed with immunomodulatory properties. Being potent autophagy inhibitors, they could lead to a form of intracellular starvation in both cytokine-releasing cells and cancer cells, thus limiting the harmful impact of CC. CQ and HCQ are also efficient in particular connective tissue disorders. They have gained special attention since the World Health Organization announced the coronavirus disease 2019 (COVID-19) pandemic. According to initial reports, people with a severe inflammatory reaction showed significant benefits. Possibly they could not be attributed to the antiviral activity alone. It is worth noting that the cytokine storm in COVID-19, connective tissue disorders, and cancer cachexia share some similarities. Therefore, we hypothesize that low doses of CQ/HCQ may prove efficient in cancer cachexia. Twit Text FOAVip Can chloroquine/hydroxychloroquine prove efficient in cancer cachexia A hypothesis in the era of COVID-19 ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33277106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33277106 #FOAvip English Wikipedia <ref>{{Cite pmid|33277106}}</ref> Can chloroquine/hydroxychloroquine prove efficient in cancer cachexia? A hypothesis in the era of COVID-19 #MMPMID33277106 Kiedrowski M; Kapala P; Kiedrowska M; Skoczynska A; Czerw A; Deptala A Med Hypotheses 2021[Jan]; 146 (?): 110434 PMID33277106show ga Cancer cachexia (CC) is a progressive loss of muscle mass (with or without a decrease of adipose tissue). Gradual deterioration of the patient's fitness is resistant to nutritional intervention. The biochemical foundation of observed catabolism, detrimental protein, and energy balance is complex. However, the generalized inflammatory response plays a vital role. It is a kind of cytokine storm, which involves increased activity of TNF-alpha, IL-1, IL-6, and INF-gamma. Pharmacological treatment of cachexia consists mainly of progestagens and glucocorticosteroids. Still, the assessment of new options limiting the harmful impact of cachexia could be beneficial. Chloroquine (CQ) and hydroxychloroquine (HCQ) are old antimalarial agents endowed with immunomodulatory properties. Being potent autophagy inhibitors, they could lead to a form of intracellular starvation in both cytokine-releasing cells and cancer cells, thus limiting the harmful impact of CC. CQ and HCQ are also efficient in particular connective tissue disorders. They have gained special attention since the World Health Organization announced the coronavirus disease 2019 (COVID-19) pandemic. According to initial reports, people with a severe inflammatory reaction showed significant benefits. Possibly they could not be attributed to the antiviral activity alone. It is worth noting that the cytokine storm in COVID-19, connective tissue disorders, and cancer cachexia share some similarities. Therefore, we hypothesize that low doses of CQ/HCQ may prove efficient in cancer cachexia. |*Models, Biological[MESH] |Autophagy/drug effects/immunology[MESH] |COVID-19 Drug Treatment[MESH] |Cachexia/*drug therapy/*etiology[MESH] |Chloroquine/*therapeutic use[MESH] |Cytokine Release Syndrome/drug therapy/etiology[MESH] |Cytokines/immunology[MESH] |Humans[MESH] |Hydroxychloroquine/*therapeutic use[MESH] |Immunologic Factors/therapeutic use[MESH] |Neoplasms/*complications[MESH] |Pandemics[MESH]Can chloroquine/hydroxychloroquine prove efficient in cancer cachexia?(epmc).pdf DeepDyve Pubget Overpricing