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10.1038/s41586-020-03041-6 http://scihub22266oqcxt.onion/10.1038/s41586-020-03041-6 33276369!7906955!33276369     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2021 ; 590 (7847): 630-634 Nephropedia Template TP {{tp|p=33276369|t=2021. Correlates of protection against SARS-CoV-2 in rhesus macaques |pdf=|usr=}}{{33276369}} gab.com Text Correlates of protection against SARS-CoV-2 in rhesus macaques JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=33276369 #FOAvip Recent studies have reported the protective efficacy of both natural(1) and vaccine-induced(2-7) immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8(+) T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents. Twit Text FOAVip Correlates of protection against SARS-CoV-2 in rhesus macaques ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=33276369 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33276369 #FOAvip English Wikipedia <ref>{{Cite pmid|33276369}}</ref> Correlates of protection against SARS-CoV-2 in rhesus macaques #MMPMID33276369 McMahan K; Yu J; Mercado NB; Loos C; Tostanoski LH; Chandrashekar A; Liu J; Peter L; Atyeo C; Zhu A; Bondzie EA; Dagotto G; Gebre MS; Jacob-Dolan C; Li Z; Nampanya F; Patel S; Pessaint L; Van Ry A; Blade K; Yalley-Ogunro J; Cabus M; Brown R; Cook A; Teow E; Andersen H; Lewis MG; Lauffenburger DA; Alter G; Barouch DH Nature 2021[Feb]; 590 (7847): 630-634 PMID33276369show ga Recent studies have reported the protective efficacy of both natural(1) and vaccine-induced(2-7) immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8(+) T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents. |*Disease Models, Animal[MESH] |Adoptive Transfer[MESH] |Animals[MESH] |CD8-Positive T-Lymphocytes/cytology/immunology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*immunology/*prevention & control/*therapy/virology[MESH] |Female[MESH] |Immunization, Passive[MESH] |Immunoglobulin G/administration & dosage/analysis/immunology[MESH] |Macaca mulatta/immunology/virology[MESH] |Male[MESH] |Regression Analysis[MESH] |SARS-CoV-2/*immunology[MESH]Correlates of protection against SARS-CoV-2 in rhesus macaques (epmc).pdf DeepDyve Pubget Overpricing