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10.1016/j.lfs.2020.118825 http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.118825 33275989!ä!33275989 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33275989&cmd=llinks): Failed to open stream: HTTP request failed! 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Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis |pdf=|usr=}}{{33275989}} gab.com Text Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33275989 #FOAvip AIMS: Ischemic renal disease (IRD) can cause kidney damage and eventually lead to end-stage renal disease. Adiponectin (APN), a recently discovered collagen-like protein secreted by adipose tissues, plays an important role in regulating energy metabolism and inflammation. This study aimed to explore the specific mechanism by which APN affects IRD. MAIN METHODS: We cultured human renal tubular epithelial cells (HK-2) and created a mouse model of IRD to detect apoptosis-related indicators in vitro and in vivo. KEY FINDINGS: Compared with those in the control group, the apoptosis rate and expression levels of Bax and Fas increased in the CoCl(2)-induced hypoxia model group. However, the expression of Bcl-2 decreased, and after the combined treatment with APN, the phenomenon mentioned above was reversed. Moreover, studies have found that stanniocalcin-1 (STC-1) and uncoupling protein3 (UCP3) are also involved in the protective effect of APN. Additionally, we found that the glomeruli of the mice were significantly enlarged after the APN gene was knocked out; furthermore, the number of collagen fibers in the renal tubules, as well as the expression of the corresponding fibrogenic factors, increased significantly. More importantly, after the knockout of the APN gene, the expression of the hypoxia-inducible factors HIF-1alpha and HIF-1beta and the apoptotic rate of renal tissue cells also increased. SIGNIFICANCE: These results indicate that APN can alleviate the symptoms of IRD by inhibiting renal cell apoptosis. Thus, in the future, APN may be a new target for the treatment of IRD. CHEMICAL COMPOUNDS: Cobalt chloride (PubChem CID: 24643). Twit Text FOAVip Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33275989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33275989 #FOAvip English Wikipedia <ref>{{Cite pmid|33275989}}</ref> Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis #MMPMID33275989 Zheng X; Liu D Life Sci 2021[Jan]; 265 (ä): 118825 PMID33275989show ga AIMS: Ischemic renal disease (IRD) can cause kidney damage and eventually lead to end-stage renal disease. Adiponectin (APN), a recently discovered collagen-like protein secreted by adipose tissues, plays an important role in regulating energy metabolism and inflammation. This study aimed to explore the specific mechanism by which APN affects IRD. MAIN METHODS: We cultured human renal tubular epithelial cells (HK-2) and created a mouse model of IRD to detect apoptosis-related indicators in vitro and in vivo. KEY FINDINGS: Compared with those in the control group, the apoptosis rate and expression levels of Bax and Fas increased in the CoCl(2)-induced hypoxia model group. However, the expression of Bcl-2 decreased, and after the combined treatment with APN, the phenomenon mentioned above was reversed. Moreover, studies have found that stanniocalcin-1 (STC-1) and uncoupling protein3 (UCP3) are also involved in the protective effect of APN. Additionally, we found that the glomeruli of the mice were significantly enlarged after the APN gene was knocked out; furthermore, the number of collagen fibers in the renal tubules, as well as the expression of the corresponding fibrogenic factors, increased significantly. More importantly, after the knockout of the APN gene, the expression of the hypoxia-inducible factors HIF-1alpha and HIF-1beta and the apoptotic rate of renal tissue cells also increased. SIGNIFICANCE: These results indicate that APN can alleviate the symptoms of IRD by inhibiting renal cell apoptosis. Thus, in the future, APN may be a new target for the treatment of IRD. CHEMICAL COMPOUNDS: Cobalt chloride (PubChem CID: 24643). |Adiponectin/genetics/*metabolism[MESH] |Animals[MESH] |Apoptosis/*physiology[MESH] |Aryl Hydrocarbon Receptor Nuclear Translocator/genetics[MESH] |Cell Line[MESH] |Collagen/metabolism[MESH] |Disease Models, Animal[MESH] |Epithelial Cells/pathology[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics[MESH] |Ischemia/physiopathology[MESH] |Kidney Diseases/*physiopathology[MESH] |Kidney Tubules/cytology/*pathology[MESH] |Male[MESH] |Mice[MESH]Adiponectin alleviates the symptoms of ischemic renal disease by inhib(epmc).pdf DeepDyve Pubget Overpricing