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10.1093/ajcp/aqaa231 http://scihub22266oqcxt.onion/10.1093/ajcp/aqaa231 33269374!7799218!33269374     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33269374&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Am+J+Clin+Pathol 2021 ; 155 (3): 364-375 Nephropedia Template TP {{tp|p=33269374|t=2021. Clinical Significance of CBC and WBC Morphology in the Diagnosis and Clinical Course of COVID-19 Infection |pdf=|usr=}}{{33269374}} gab.com Text Clinical Significance of CBC and WBC Morphology in the Diagnosis and Clinical Course of COVID-19 Infection JO: Am J Clin Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33269374 #FOAvip OBJECTIVES: To investigate the clinical significance of numeric and morphologic peripheral blood (PB) changes in coronavirus disease 2019 (COVID-19)-positive patients in predicting the outcome, as well as to compare these changes between critically ill COVID-19-positive and COVID-19-negative patients. METHODS: The study included 90 COVID-19-positive (51 intensive care unit [ICU] and 39 non-ICU) patients and 30 COVID-19-negative ICU patients. We collected CBC parameters (both standard and research) and PB morphologic findings, which were independently scored by two hematopathologists. RESULTS: All patients with COVID-19 demonstrated striking numeric and morphologic WBC changes, which were different between mild and severe disease states. More severe disease was associated with significant neutrophilia and lymphopenia, which was intensified in critically ill patients. Abnormal WBC morphology, most pronounced in monocytes and lymphocytes, was associated with more mild disease; the changes were lost with disease progression. Between COVID-19-positive and COVID-19-negative ICU patients, significant differences in morphology-associated research parameters were indicative of changes due to the severe acute respiratory syndrome coronavirus 2 virus, including higher RNA content in monocytes, lower RNA content in lymphocytes, and smaller hypogranular neutrophils. CONCLUSIONS: Hospitalized patients with COVID-19 should undergo a comprehensive daily CBC with manual WBC differential to monitor for numerical and morphologic changes predictive of poor outcome and signs of disease progression. Twit Text FOAVip Clinical Significance of CBC and WBC Morphology in the Diagnosis and Clinical Course of COVID-19 Infection ????Am J Clin Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33269374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33269374 #FOAvip English Wikipedia <ref>{{Cite pmid|33269374}}</ref> Clinical Significance of CBC and WBC Morphology in the Diagnosis and Clinical Course of COVID-19 Infection #MMPMID33269374 Pozdnyakova O; Connell NT; Battinelli EM; Connors JM; Fell G; Kim AS Am J Clin Pathol 2021[Feb]; 155 (3): 364-375 PMID33269374show ga OBJECTIVES: To investigate the clinical significance of numeric and morphologic peripheral blood (PB) changes in coronavirus disease 2019 (COVID-19)-positive patients in predicting the outcome, as well as to compare these changes between critically ill COVID-19-positive and COVID-19-negative patients. METHODS: The study included 90 COVID-19-positive (51 intensive care unit [ICU] and 39 non-ICU) patients and 30 COVID-19-negative ICU patients. We collected CBC parameters (both standard and research) and PB morphologic findings, which were independently scored by two hematopathologists. RESULTS: All patients with COVID-19 demonstrated striking numeric and morphologic WBC changes, which were different between mild and severe disease states. More severe disease was associated with significant neutrophilia and lymphopenia, which was intensified in critically ill patients. Abnormal WBC morphology, most pronounced in monocytes and lymphocytes, was associated with more mild disease; the changes were lost with disease progression. Between COVID-19-positive and COVID-19-negative ICU patients, significant differences in morphology-associated research parameters were indicative of changes due to the severe acute respiratory syndrome coronavirus 2 virus, including higher RNA content in monocytes, lower RNA content in lymphocytes, and smaller hypogranular neutrophils. CONCLUSIONS: Hospitalized patients with COVID-19 should undergo a comprehensive daily CBC with manual WBC differential to monitor for numerical and morphologic changes predictive of poor outcome and signs of disease progression. |Aged[MESH] |Blood Cell Count[MESH] |COVID-19/*blood/*complications/pathology[MESH] |Critical Illness[MESH] |Disease Progression[MESH] |Female[MESH] |Humans[MESH] |Leukocyte Count[MESH] |Leukocytes/*pathology[MESH] |Lymphopenia/*virology[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/*pathology[MESH]Clinical Significance of CBC and WBC Morphology in the Diagnosis and C(epmc).pdf DeepDyve Pubget Overpricing