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10.14336/AD.2020.0225 http://scihub22266oqcxt.onion/10.14336/AD.2020.0225 33269106!7673857!33269106     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+Dis 2020 ; 11 (6): 1537-1566 Nephropedia Template TP {{tp|p=33269106|t=2020. Oxidative Stress at the Crossroads of Aging, Stroke and Depression |pdf=|usr=}}{{33269106}} gab.com Text Oxidative Stress at the Crossroads of Aging, Stroke and Depression JO: Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=33269106 #FOAvip Epidemiologic studies have shown that in the aging society, a person dies from stroke every 3 minutes and 42 seconds, and vast numbers of people experience depression around the globe. The high prevalence and disability rates of stroke and depression introduce enormous challenges to public health. Accumulating evidence reveals that stroke is tightly associated with depression, and both diseases are linked to oxidative stress (OS). This review summarizes the mechanisms of OS and OS-mediated pathological processes, such as inflammation, apoptosis, and the microbial-gut-brain axis in stroke and depression. Pathological changes can lead to neuronal cell death, neurological deficits, and brain injury through DNA damage and the oxidation of lipids and proteins, which exacerbate the development of these two disorders. Additionally, aging accelerates the progression of stroke and depression by overactive OS and reduced antioxidant defenses. This review also discusses the efficacy and safety of several antioxidants and antidepressants in stroke and depression. Herein, we propose a crosstalk between OS, aging, stroke, and depression, and provide potential therapeutic strategies for the treatment of stroke and depression. Twit Text FOAVip Oxidative Stress at the Crossroads of Aging, Stroke and Depression ????Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=33269106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33269106 #FOAvip English Wikipedia <ref>{{Cite pmid|33269106}}</ref> Oxidative Stress at the Crossroads of Aging, Stroke and Depression #MMPMID33269106 Shao A; Lin D; Wang L; Tu S; Lenahan C; Zhang J Aging Dis 2020[Dec]; 11 (6): 1537-1566 PMID33269106show ga Epidemiologic studies have shown that in the aging society, a person dies from stroke every 3 minutes and 42 seconds, and vast numbers of people experience depression around the globe. The high prevalence and disability rates of stroke and depression introduce enormous challenges to public health. Accumulating evidence reveals that stroke is tightly associated with depression, and both diseases are linked to oxidative stress (OS). This review summarizes the mechanisms of OS and OS-mediated pathological processes, such as inflammation, apoptosis, and the microbial-gut-brain axis in stroke and depression. Pathological changes can lead to neuronal cell death, neurological deficits, and brain injury through DNA damage and the oxidation of lipids and proteins, which exacerbate the development of these two disorders. Additionally, aging accelerates the progression of stroke and depression by overactive OS and reduced antioxidant defenses. This review also discusses the efficacy and safety of several antioxidants and antidepressants in stroke and depression. Herein, we propose a crosstalk between OS, aging, stroke, and depression, and provide potential therapeutic strategies for the treatment of stroke and depression. äOxidative Stress at the Crossroads of Aging, Stroke and Depression (epmc).pdf DeepDyve Pubget Overpricing