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10.14336/AD.2020.0603 http://scihub22266oqcxt.onion/10.14336/AD.2020.0603 33269094!7673842!33269094     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+Dis 2020 ; 11 (6): 1363-1373 Nephropedia Template TP {{tp|p=33269094|t=2020. Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience |pdf=|usr=}}{{33269094}} gab.com Text Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience JO: Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=33269094 #FOAvip The interrelation of the processes of immunity and senescence now receives an unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the critical need to combat immunosenescence and improve the immune function and resilience of older persons. Here we review the historical origins and the current state of the science of innate and adaptive immunity in aging and longevity. From the modern point of view, innate and adaptive immunity are not only affected by aging but also are important parts of its underlying mechanisms. Excessive levels or activity of antimicrobial peptides, C-reactive protein, complement system, TLR/NF-kappaB, cGAS/STING/IFN 1,3 and AGEs/RAGE pathways, myeloid cells and NLRP3 inflammasome, declined levels of NK cells in innate immunity, thymus involution and decreased amount of naive T-cells in adaptive immunity, are biomarkers of aging and predisposition factors for cellular senescence and aging-related pathologies. Long-living species, human centenarians, and women are characterized by less inflamm-aging and decelerated immunosenescence. Despite recent progress in understanding, the harmonious theory of immunosenescence is still developing. Geroprotectors targeting these mechanisms are just emerging and are comprehensively discussed in this article. Twit Text FOAVip Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience ????Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=33269094 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33269094 #FOAvip English Wikipedia <ref>{{Cite pmid|33269094}}</ref> Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience #MMPMID33269094 Moskalev A; Stambler I; Caruso C Aging Dis 2020[Dec]; 11 (6): 1363-1373 PMID33269094show ga The interrelation of the processes of immunity and senescence now receives an unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the critical need to combat immunosenescence and improve the immune function and resilience of older persons. Here we review the historical origins and the current state of the science of innate and adaptive immunity in aging and longevity. From the modern point of view, innate and adaptive immunity are not only affected by aging but also are important parts of its underlying mechanisms. Excessive levels or activity of antimicrobial peptides, C-reactive protein, complement system, TLR/NF-kappaB, cGAS/STING/IFN 1,3 and AGEs/RAGE pathways, myeloid cells and NLRP3 inflammasome, declined levels of NK cells in innate immunity, thymus involution and decreased amount of naive T-cells in adaptive immunity, are biomarkers of aging and predisposition factors for cellular senescence and aging-related pathologies. Long-living species, human centenarians, and women are characterized by less inflamm-aging and decelerated immunosenescence. Despite recent progress in understanding, the harmonious theory of immunosenescence is still developing. Geroprotectors targeting these mechanisms are just emerging and are comprehensively discussed in this article. äInnate and Adaptive Immunity in Aging and Longevity: The Foundation of(epmc).pdf DeepDyve Pubget Overpricing