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10.3390/ijms21239111

http://scihub22266oqcxt.onion/10.3390/ijms21239111
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33266211!7729475!33266211
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suck abstract from ncbi


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pmid33266211      Int+J+Mol+Sci 2020 ; 21 (23): ä
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  • The Role of Extracellular Vesicles in Demyelination of the Central Nervous System #MMPMID33266211
  • Lopez-Guerrero JA; Ripa I; Andreu S; Bello-Morales R
  • Int J Mol Sci 2020[Nov]; 21 (23): ä PMID33266211show ga
  • It is being increasingly demonstrated that extracellular vesicles (EVs) are deeply involved in the physiology of the central nervous system (CNS). Processes such as synaptic activity, neuron-glia communication, myelination and immune response are modulated by EVs. Likewise, these vesicles may participate in many pathological processes, both as triggers of disease or, on the contrary, as mechanisms of repair. EVs play relevant roles in neurodegenerative disorders such as Alzheimer's or Parkinson's diseases, in viral infections of the CNS and in demyelinating pathologies such as multiple sclerosis (MS). This review describes the involvement of these membrane vesicles in major demyelinating diseases, including MS, neuromyelitis optica, progressive multifocal leukoencephalopathy and demyelination associated to herpesviruses.
  • |Animals[MESH]
  • |Central Nervous System/*pathology[MESH]
  • |Demyelinating Diseases/*pathology[MESH]
  • |Endogenous Retroviruses/physiology[MESH]
  • |Extracellular Vesicles/*metabolism[MESH]
  • |Humans[MESH]


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