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10.3390/v12121367 http://scihub22266oqcxt.onion/10.3390/v12121367 33265982!7760740!33265982     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (12): ä Nephropedia Template TP {{tp|p=33265982|t=2020. Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System |pdf=|usr=}}{{33265982}} gab.com Text Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33265982 #FOAvip SARS-CoV-2 infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors associated with COVID-19 coronavirus disease and to design effective therapeutic strategies. In this context, we developed a mathematical model of RAS based on data regarding protein and peptide concentrations; the model was tested on clinical data from healthy normotensive and hypertensive individuals. We used our model to analyze the impact of SARS-CoV-2 infection on RAS, which we modeled through a downregulation of ACE2 as a function of viral load. We also used it to predict the effect of RAS-targeting drugs, such as RAS-blockers, human recombinant ACE2, and angiotensin 1-7 peptide, on COVID-19 patients; the model predicted an improvement of the clinical outcome for some drugs and a worsening for others. Our model and its predictions constitute a valuable framework for in silico testing of hypotheses about the COVID-19 pathogenic mechanisms and the effect of drugs aiming to restore RAS functionality. Twit Text FOAVip Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33265982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33265982 #FOAvip English Wikipedia <ref>{{Cite pmid|33265982}}</ref> Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System #MMPMID33265982 Pucci F; Bogaerts P; Rooman M Viruses 2020[Nov]; 12 (12): ä PMID33265982show ga SARS-CoV-2 infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors associated with COVID-19 coronavirus disease and to design effective therapeutic strategies. In this context, we developed a mathematical model of RAS based on data regarding protein and peptide concentrations; the model was tested on clinical data from healthy normotensive and hypertensive individuals. We used our model to analyze the impact of SARS-CoV-2 infection on RAS, which we modeled through a downregulation of ACE2 as a function of viral load. We also used it to predict the effect of RAS-targeting drugs, such as RAS-blockers, human recombinant ACE2, and angiotensin 1-7 peptide, on COVID-19 patients; the model predicted an improvement of the clinical outcome for some drugs and a worsening for others. Our model and its predictions constitute a valuable framework for in silico testing of hypotheses about the COVID-19 pathogenic mechanisms and the effect of drugs aiming to restore RAS functionality. |*Models, Theoretical[MESH] |Angiotensin I/administration & dosage/pharmacology[MESH] |Angiotensin Receptor Antagonists/administration & dosage/pharmacology[MESH] |Angiotensin-Converting Enzyme 2/administration & dosage/metabolism[MESH] |Angiotensin-Converting Enzyme Inhibitors/administration & dosage/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*pathology/virology[MESH] |Computer Simulation[MESH] |Humans[MESH] |Peptide Fragments/administration & dosage/pharmacology[MESH] |Renin-Angiotensin System/drug effects/*physiology[MESH] |Renin/antagonists & inhibitors[MESH] |SARS-CoV-2[MESH]Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Ang(epmc).pdf DeepDyve Pubget Overpricing