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10.1371/journal.pone.0242318 http://scihub22266oqcxt.onion/10.1371/journal.pone.0242318 33264297!7710059!33264297     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2020 ; 15 (12): e0242318 Nephropedia Template TP {{tp|p=33264297|t=2020. Colchicine reduces lung injury in experimental acute respiratory distress syndrome |pdf=|usr=}}{{33264297}} gab.com Text Colchicine reduces lung injury in experimental acute respiratory distress syndrome JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33264297 #FOAvip The acute respiratory distress syndrome (ARDS) is characterized by intense dysregulated inflammation leading to acute lung injury (ALI) and respiratory failure. There are no effective pharmacologic therapies for ARDS. Colchicine is a low-cost, widely available drug, effective in the treatment of inflammatory conditions. We studied the effects of colchicine pre-treatment on oleic acid-induced ARDS in rats. Rats were treated with colchicine (1 mg/kg) or placebo for three days prior to intravenous oleic acid-induced ALI (150 mg/kg). Four hours later they were studied and compared to a sham group. Colchicine reduced the area of histological lung injury by 61%, reduced lung edema, and markedly improved oxygenation by increasing PaO2/FiO2 from 66 +/- 13 mmHg (mean +/- SEM) to 246 +/- 45 mmHg compared to 380 +/- 18 mmHg in sham animals. Colchicine also reduced PaCO2 and respiratory acidosis. Lung neutrophil recruitment, assessed by myeloperoxidase immunostaining, was greatly increased after injury from 1.16 +/- 0.19% to 8.86 +/- 0.66% and significantly reduced by colchicine to 5.95 +/- 1.13%. Increased lung NETosis was also reduced by therapy. Circulating leukocytosis after ALI was not reduced by colchicine therapy, but neutrophils reactivity and CD4 and CD8 cell surface expression on lymphocyte populations were restored. Colchicine reduces ALI and respiratory failure in experimental ARDS in relation with reduced lung neutrophil recruitment and reduced circulating leukocyte activation. This study supports the clinical development of colchicine for the prevention of ARDS in conditions causing ALI. Twit Text FOAVip Colchicine reduces lung injury in experimental acute respiratory distress syndrome ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33264297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33264297 #FOAvip English Wikipedia <ref>{{Cite pmid|33264297}}</ref> Colchicine reduces lung injury in experimental acute respiratory distress syndrome #MMPMID33264297 Dupuis J; Sirois MG; Rheaume E; Nguyen QT; Clavet-Lanthier ME; Brand G; Mihalache-Avram T; Theberge-Julien G; Charpentier D; Rhainds D; Neagoe PE; Tardif JC PLoS One 2020[]; 15 (12): e0242318 PMID33264297show ga The acute respiratory distress syndrome (ARDS) is characterized by intense dysregulated inflammation leading to acute lung injury (ALI) and respiratory failure. There are no effective pharmacologic therapies for ARDS. Colchicine is a low-cost, widely available drug, effective in the treatment of inflammatory conditions. We studied the effects of colchicine pre-treatment on oleic acid-induced ARDS in rats. Rats were treated with colchicine (1 mg/kg) or placebo for three days prior to intravenous oleic acid-induced ALI (150 mg/kg). Four hours later they were studied and compared to a sham group. Colchicine reduced the area of histological lung injury by 61%, reduced lung edema, and markedly improved oxygenation by increasing PaO2/FiO2 from 66 +/- 13 mmHg (mean +/- SEM) to 246 +/- 45 mmHg compared to 380 +/- 18 mmHg in sham animals. Colchicine also reduced PaCO2 and respiratory acidosis. Lung neutrophil recruitment, assessed by myeloperoxidase immunostaining, was greatly increased after injury from 1.16 +/- 0.19% to 8.86 +/- 0.66% and significantly reduced by colchicine to 5.95 +/- 1.13%. Increased lung NETosis was also reduced by therapy. Circulating leukocytosis after ALI was not reduced by colchicine therapy, but neutrophils reactivity and CD4 and CD8 cell surface expression on lymphocyte populations were restored. Colchicine reduces ALI and respiratory failure in experimental ARDS in relation with reduced lung neutrophil recruitment and reduced circulating leukocyte activation. This study supports the clinical development of colchicine for the prevention of ARDS in conditions causing ALI. |Acute Lung Injury/blood/chemically induced/*drug therapy/pathology[MESH] |Animals[MESH] |Colchicine/*pharmacology[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Lung/*drug effects/pathology[MESH] |Neutrophil Infiltration/drug effects[MESH] |Neutrophils/drug effects[MESH] |Oleic Acid/toxicity[MESH] |Rats[MESH]Colchicine reduces lung injury in experimental acute respiratory distr(epmc).pdf DeepDyve Pubget Overpricing