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10.3947/ic.2020.52.4.461

http://scihub22266oqcxt.onion/10.3947/ic.2020.52.4.461
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33263242!7779993!33263242
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suck abstract from ncbi


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pmid33263242      Infect+Chemother 2020 ; 52 (4): 461-477
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  • Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19 #MMPMID33263242
  • Farjana M; Moni A; Sohag AAM; Hasan A; Hannan MA; Hossain MG; Uddin MJ
  • Infect Chemother 2020[Dec]; 52 (4): 461-477 PMID33263242show ga
  • Vitamin C, also known as L-ascorbic acid, is an essential vitamin with pleiotropic functions, ranging from antioxidant to anti-microbial functions. Evidence suggests that vitamin C acts against inflammation, oxidative stress, autophagy chaos, and immune dysfunction. The ability to activate and enhance the immune system makes this versatile vitamin a prospective therapeutic agent amid the current situation of coronavirus disease 2019 (COVID-19). Being highly effective against the influenza virus, causing the common cold, vitamin C may also function against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its associated complications. Severe infections need higher doses of the vitamin to compensate for the augmented inflammatory response and metabolic demand that commonly occur during COVID-19. Compelling evidence also suggests that a high dose of vitamin C (1.5 g/kg body weight) in inflammatory conditions can result in effective clinical outcomes and thus can be employed to combat COVID-19. However, further studies are crucial to delineate the mechanism underlying the action of vitamin C against COVID-19. The current review aims to reposition vitamin C as an alternative approach for alleviating COVID-19-associated complications.
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