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10.1016/j.recesp.2020.09.017

http://scihub22266oqcxt.onion/10.1016/j.recesp.2020.09.017
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33262553!7691144!33262553
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suck abstract from ncbi


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pmid33262553      Rev+Esp+Cardiol 2021 ; 74 (7): 576-583
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  • Marcadores de dano miocardico en la prediccion del pronostico a corto plazo de los pacientes con COVID-19 #MMPMID33262553
  • Calvo-Fernandez A; Izquierdo A; Subirana I; Farre N; Vila J; Duran X; Garcia-Guimaraes M; Valdivielso S; Cabero P; Soler C; Garcia-Ribas C; Rodriguez C; Llagostera M; Mojon D; Vicente M; Sole-Gonzalez E; Sanchez-Carpintero A; Tevar C; Marrugat J; Vaquerizo B
  • Rev Esp Cardiol 2021[Jul]; 74 (7): 576-583 PMID33262553show ga
  • INTRODUCTION AND OBJECTIVES: COVID-19 is currently causing high mortality and morbidity worldwide. Information on cardiac injury is scarce. We aimed to evaluate cardiovascular damage in patients with COVID-19 and determine the correlation of high-sensitivity cardiac-specific troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) with the severity of COVID-19. METHODS: We included 872 consecutive patients with confirmed COVID-19 from February to April 2020. We tested 651 patients for high-sensitivity troponin T (hs-TnT) and 506 for NT-proBNP on admission. Cardiac injury was defined as hs-TnT > 14 ng/L, the upper 99th percentile. Levels of NT-proBNP > 300 pg/mL were considered related to some extent of cardiac injury. The primary composite endpoint was 30-day mortality or mechanical ventilation (MV). RESULTS: Cardiac injury by hs-TnT was observed in 34.6% of our COVID-19 patients. Mortality or MV were higher in cardiac injury than noncardiac injury patients (39.1% vs 9.1%). Hs-TnT and NT-proBNP levels were independent predictors of death or MV (HR, 2.18; 95%CI, 1.23-3.83 and 1.87 (95%CI, 1.05-3.36), respectively) and of mortality alone (HR, 2.91; 95%CI, 1.211-7.04 and 5.47; 95%CI, 2.10-14.26, respectively). NT-ProBNP significantly improved the troponin model discrimination of mortality or MV (C-index 0.83 to 0.84), and of mortality alone (C-index 0.85 to 0.87). CONCLUSIONS: Myocardial injury measured at admission was a common finding in patients with COVID-19. It reliably predicted the occurrence of mortality and need of MV, the most severe complications of the disease. NT-proBNP improved the prognostic accuracy of hs-TnT.
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