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10.1186/s40249-020-00781-5

http://scihub22266oqcxt.onion/10.1186/s40249-020-00781-5
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33261654!7707904!33261654
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suck abstract from ncbi


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pmid33261654      Infect+Dis+Poverty 2020 ; 9 (1): 163
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  • Comparison of patients hospitalized with COVID-19, H7N9 and H1N1 #MMPMID33261654
  • Deng LS; Yuan J; Ding L; Chen YL; Zhao CH; Chen GQ; Li XH; Li XH; Luo WT; Lan JF; Tan GY; Tang SH; Xia JY; Liu X
  • Infect Dis Poverty 2020[Dec]; 9 (1): 163 PMID33261654show ga
  • BACKGROUND: There is an urgent need to better understand the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for that the coronavirus disease 2019 (COVID-19) continues to cause considerable morbidity and mortality worldwide. This paper was to differentiate COVID-19 from other respiratory infectious diseases such as avian-origin influenza A (H7N9) and influenza A (H1N1) virus infections. METHODS: We included patients who had been hospitalized with laboratory-confirmed infection by SARS-CoV-2 (n = 83), H7N9 (n = 36), H1N1 (n = 44) viruses. Clinical presentation, chest CT features, and progression of patients were compared. We used the Logistic regression model to explore the possible risk factors. RESULTS: Both COVID-19 and H7N9 patients had a longer duration of hospitalization than H1N1 patients (P < 0.01), a higher complication rate, and more severe cases than H1N1 patients. H7N9 patients had higher hospitalization-fatality ratio than COVID-19 patients (P = 0.01). H7N9 patients had similar patterns of lymphopenia, neutrophilia, elevated alanine aminotransferase, C-reactive protein, lactate dehydrogenase, and those seen in H1N1 patients, which were all significantly different from patients with COVID-19 (P < 0.01). Either H7N9 or H1N1 patients had more obvious symptoms, like fever, fatigue, yellow sputum, and myalgia than COVID-19 patients (P < 0.01). The mean duration of viral shedding was 9.5 days for SARS-CoV-2 vs 9.9 days for H7N9 (P = 0.78). For severe cases, the meantime from illness onset to severity was 8.0 days for COVID-19 vs 5.2 days for H7N9 (P < 0.01), the comorbidity of chronic heart disease was more common in the COVID-19 patients than H7N9 (P = 0.02). Multivariate analysis showed that chronic heart disease was a possible risk factor (OR > 1) for COVID-19, compared with H1N1 and H7N9. CONCLUSIONS: The proportion of severe cases were higher for H7N9 and SARS-CoV-2 infections, compared with H1N1. The meantime from illness onset to severity was shorter for H7N9. Chronic heart disease was a possible risk factor for COVID-19.The comparison may provide the rationale for strategies of isolation and treatment of infected patients in the future.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/diagnosis/mortality/*pathology/*virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Comorbidity[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Influenza A Virus, H1N1 Subtype/pathogenicity[MESH]
  • |Influenza A Virus, H7N9 Subtype/pathogenicity[MESH]
  • |Influenza, Human/diagnosis/mortality/*pathology/*virology[MESH]
  • |Lung/diagnostic imaging/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/pathogenicity[MESH]
  • |Virus Shedding[MESH]


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