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10.3390/ijms21239077 http://scihub22266oqcxt.onion/10.3390/ijms21239077 33260670!7731221!33260670     free     free     free Deprecated: Implicit conversion from float 205.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 205.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 205.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 205.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (23): ä Nephropedia Template TP {{tp|p=33260670|t=2020. In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein Extracts |pdf=|usr=}}{{33260670}} gab.com Text In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein Extracts JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33260670 #FOAvip Bovine immunoglobulin G (bIgG) was previously shown to enhance innate immune responses to toll-like receptor (TLR) stimulation, via induction of trained immunity. In this study, we investigated whether minimally processed dairy streams with high levels of whey proteins as potential infant nutrition ingredients could also induce trained immunity, and to what extent this can be explained by the presence of bIgG. The minimally processed whey ingredients serum protein concentrate (SPC) and whey protein concentrate (WPC) were tested for their ability to induce trained immunity in human peripheral blood monocytes. Both ingredients induced trained immunity as evidenced by an increased production of TNF-alpha and, to a lesser extent, of IL-6 upon stimulation with TLR ligands. This was comparable to isolated bovine immunoglobulin G (bIgG) that served as positive control. Depletion of bIgG from both whey protein-containing ingredients did not significantly inhibit the induction of trained immunity, suggesting that the streams contain other components in addition to bIgG that are able to induce trained immunity. These results indicate that minimally processed whey ingredients may contribute to protection against infections through enhancing innate immune responsiveness to pathogens. Twit Text FOAVip In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein Extracts ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33260670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33260670 #FOAvip English Wikipedia <ref>{{Cite pmid|33260670}}</ref> In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein Extracts #MMPMID33260670 Hellinga AH; Tsallis T; Eshuis T; Triantis V; Ulfman LH; Neerven RJJV Int J Mol Sci 2020[Nov]; 21 (23): ä PMID33260670show ga Bovine immunoglobulin G (bIgG) was previously shown to enhance innate immune responses to toll-like receptor (TLR) stimulation, via induction of trained immunity. In this study, we investigated whether minimally processed dairy streams with high levels of whey proteins as potential infant nutrition ingredients could also induce trained immunity, and to what extent this can be explained by the presence of bIgG. The minimally processed whey ingredients serum protein concentrate (SPC) and whey protein concentrate (WPC) were tested for their ability to induce trained immunity in human peripheral blood monocytes. Both ingredients induced trained immunity as evidenced by an increased production of TNF-alpha and, to a lesser extent, of IL-6 upon stimulation with TLR ligands. This was comparable to isolated bovine immunoglobulin G (bIgG) that served as positive control. Depletion of bIgG from both whey protein-containing ingredients did not significantly inhibit the induction of trained immunity, suggesting that the streams contain other components in addition to bIgG that are able to induce trained immunity. These results indicate that minimally processed whey ingredients may contribute to protection against infections through enhancing innate immune responsiveness to pathogens. |*Immunity, Innate[MESH] |Animals[MESH] |Blood Proteins/metabolism[MESH] |Cattle[MESH] |Cells, Cultured[MESH] |Humans[MESH] |Immunoglobulin G/*metabolism[MESH] |Monocytes/immunology[MESH]In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein(epmc).pdf DeepDyve Pubget Overpricing