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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nature 2021 ; 590 (7845): 320-325 Nephropedia Template TP
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A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate #MMPMID33260195
Sanchez-Felipe L; Vercruysse T; Sharma S; Ma J; Lemmens V; Van Looveren D; Arkalagud Javarappa MP; Boudewijns R; Malengier-Devlies B; Liesenborghs L; Kaptein SJF; De Keyzer C; Bervoets L; Debaveye S; Rasulova M; Seldeslachts L; Li LH; Jansen S; Yakass MB; Verstrepen BE; Boszormenyi KP; Kiemenyi-Kayere G; van Driel N; Quaye O; Zhang X; Ter Horst S; Mishra N; Deboutte W; Matthijnssens J; Coelmont L; Vandermeulen C; Heylen E; Vergote V; Schols D; Wang Z; Bogers W; Kuiken T; Verschoor E; Cawthorne C; Van Laere K; Opdenakker G; Vande Velde G; Weynand B; Teuwen DE; Matthys P; Neyts J; Jan Thibaut H; Dallmeier K
Nature 2021[Feb]; 590 (7845): 320-325 PMID33260195show ga
The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being leveraged for a rapid emergency response(1). Here we describe the development of a candidate vaccine (YF-S0) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses live-attenuated yellow fever 17D (YF17D) vaccine as a vector to express a noncleavable prefusion form of the SARS-CoV-2 spike antigen. We assess vaccine safety, immunogenicity and efficacy in several animal models. YF-S0 has an excellent safety profile and induces high levels of SARS-CoV-2 neutralizing antibodies in hamsters (Mesocricetus auratus), mice (Mus musculus) and cynomolgus macaques (Macaca fascicularis), and-concomitantly-protective immunity against yellow fever virus. Humoral immunity is complemented by a cellular immune response with favourable T helper 1 polarization, as profiled in mice. In a hamster model(2) and in macaques, YF-S0 prevents infection with SARS-CoV-2. Moreover, a single dose conferred protection from lung disease in most of the vaccinated hamsters within as little as 10 days. Taken together, the quality of the immune responses triggered and the rapid kinetics by which protective immunity can be attained after a single dose warrant further development of this potent SARS-CoV-2 vaccine candidate.
Nature 2021 ; 590 (7845): 320-325
