COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study #MMPMID33260010
Longobardo A; Snow TAC; Montanari C; Shulman R; Singer M; Arulkumaran N
J Crit Care 2021[Apr]; 62 (?): 46-48 PMID33260010show ga
Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO(2): FiO(2) ratio (p = 0.046) following low-dose steroid treatment, unlike patients with non-COVID ARDS (n = 16) (p = 0.529). Patients with COVID-19 ARDS had a greater fall in CRP compared to patients with non-COVID ARDS, albeit not statistically significant (p = 0.07). Our novel findings highlight differences in the underlying physiological and immunological phenotypes between COVID-19 and non-COVID ARDS, with implications for future ARDS studies.