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10.1016/j.jinf.2020.11.031 http://scihub22266oqcxt.onion/10.1016/j.jinf.2020.11.031 33259846!7698677!33259846     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect 2021 ; 82 (1): 126-132 Nephropedia Template TP {{tp|p=33259846|t=2021. Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19 |pdf=|usr=}}{{33259846}} gab.com Text Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19 JO: J Infect http://www.kidney.de/pget.php?&tw=1&pmid=33259846 #FOAvip OBJECTIVES: COVID-19 has caused a large global pandemic. Patients with COVID-19 exhibited considerable variation in disease behavior. Pervious genome-wide association studies have identified potential genetic variants involved in the risk and prognosis of COVID-19, but the underlying biological interpretation remains largely unclear. METHODS: We applied the summary data-based Mendelian randomization (SMR) method to identify genes that were pleiotropically associated with the risk and various outcomes of COVID-19, including severe respiratory confirmed COVID-19 and hospitalized COVID-19. RESULTS: In blood, we identified 2 probes, ILMN_1765146 and ILMN_1791057 tagging IFNAR2, that showed pleiotropic association with hospitalized COVID-19 (beta [SE]=0.42 [0.09], P?=?4.75?x?10(-06) and beta [SE]=-0.48 [0.11], P?=?6.76?x?10(-06), respectively). Although no other probes were significant after correction for multiple testing in both blood and lung, multiple genes as tagged by the top 5 probes were involved in inflammation or antiviral immunity, and several other tagged genes, such as PON2 and HPS5, were involved in blood coagulation. CONCLUSIONS: We identified IFNAR2 and other potential genes that could be involved in the susceptibility or prognosis of COVID-19. These findings provide important leads to a better understanding of the mechanisms of cytokine storm and venous thromboembolism in COVID-19 and potential therapeutic targets for the effective treatment of COVID-19. Twit Text FOAVip Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19 ????J Infect http://www.kidney.de/pget.php?&tw=1&pmid=33259846 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33259846 #FOAvip English Wikipedia <ref>{{Cite pmid|33259846}}</ref> Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19 #MMPMID33259846 Liu D; Yang J; Feng B; Lu W; Zhao C; Li L J Infect 2021[Jan]; 82 (1): 126-132 PMID33259846show ga OBJECTIVES: COVID-19 has caused a large global pandemic. Patients with COVID-19 exhibited considerable variation in disease behavior. Pervious genome-wide association studies have identified potential genetic variants involved in the risk and prognosis of COVID-19, but the underlying biological interpretation remains largely unclear. METHODS: We applied the summary data-based Mendelian randomization (SMR) method to identify genes that were pleiotropically associated with the risk and various outcomes of COVID-19, including severe respiratory confirmed COVID-19 and hospitalized COVID-19. RESULTS: In blood, we identified 2 probes, ILMN_1765146 and ILMN_1791057 tagging IFNAR2, that showed pleiotropic association with hospitalized COVID-19 (beta [SE]=0.42 [0.09], P?=?4.75?x?10(-06) and beta [SE]=-0.48 [0.11], P?=?6.76?x?10(-06), respectively). Although no other probes were significant after correction for multiple testing in both blood and lung, multiple genes as tagged by the top 5 probes were involved in inflammation or antiviral immunity, and several other tagged genes, such as PON2 and HPS5, were involved in blood coagulation. CONCLUSIONS: We identified IFNAR2 and other potential genes that could be involved in the susceptibility or prognosis of COVID-19. These findings provide important leads to a better understanding of the mechanisms of cytokine storm and venous thromboembolism in COVID-19 and potential therapeutic targets for the effective treatment of COVID-19. |*Mendelian Randomization Analysis[MESH] |Aryldialkylphosphatase/genetics[MESH] |Blood Coagulation/genetics[MESH] |COVID-19/*epidemiology/mortality[MESH] |Carrier Proteins/genetics[MESH] |Cytokine Release Syndrome/genetics/pathology[MESH] |Genetic Predisposition to Disease/genetics[MESH] |Genetic Variation/*genetics[MESH] |Genome-Wide Association Study/*methods[MESH] |Humans[MESH] |Prognosis[MESH] |Receptor, Interferon alpha-beta/genetics[MESH] |Risk[MESH] |SARS-CoV-2/*genetics[MESH]Mendelian randomization analysis identified genes pleiotropically asso(epmc).pdf DeepDyve Pubget Overpricing