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10.1016/j.molcel.2020.11.028 http://scihub22266oqcxt.onion/10.1016/j.molcel.2020.11.028 33259812!7674017!33259812     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33259812.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2020 ; 80 (6): 1104-1122.e9 Nephropedia Template TP {{tp|p=33259812|t=2020. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 |pdf=|usr=}}{{33259812}} gab.com Text Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=33259812 #FOAvip Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic crisis. The virus infects alveolar epithelial type 2 cells (AT2s), leading to lung injury and impaired gas exchange, but the mechanisms driving infection and pathology are unclear. We performed a quantitative phosphoproteomic survey of induced pluripotent stem cell-derived AT2s (iAT2s) infected with SARS-CoV-2 at air-liquid interface (ALI). Time course analysis revealed rapid remodeling of diverse host systems, including signaling, RNA processing, translation, metabolism, nuclear integrity, protein trafficking, and cytoskeletal-microtubule organization, leading to cell cycle arrest, genotoxic stress, and innate immunity. Comparison to analogous data from transformed cell lines revealed respiratory-specific processes hijacked by SARS-CoV-2, highlighting potential novel therapeutic avenues that were validated by a high hit rate in a targeted small molecule screen in our iAT2 ALI system. Twit Text FOAVip Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=33259812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33259812 #FOAvip English Wikipedia <ref>{{Cite pmid|33259812}}</ref> Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 #MMPMID33259812 Hekman RM; Hume AJ; Goel RK; Abo KM; Huang J; Blum BC; Werder RB; Suder EL; Paul I; Phanse S; Youssef A; Alysandratos KD; Padhorny D; Ojha S; Mora-Martin A; Kretov D; Ash PEA; Verma M; Zhao J; Patten JJ; Villacorta-Martin C; Bolzan D; Perea-Resa C; Bullitt E; Hinds A; Tilston-Lunel A; Varelas X; Farhangmehr S; Braunschweig U; Kwan JH; McComb M; Basu A; Saeed M; Perissi V; Burks EJ; Layne MD; Connor JH; Davey R; Cheng JX; Wolozin BL; Blencowe BJ; Wuchty S; Lyons SM; Kozakov D; Cifuentes D; Blower M; Kotton DN; Wilson AA; Muhlberger E; Emili A Mol Cell 2020[Dec]; 80 (6): 1104-1122.e9 PMID33259812show ga Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic crisis. The virus infects alveolar epithelial type 2 cells (AT2s), leading to lung injury and impaired gas exchange, but the mechanisms driving infection and pathology are unclear. We performed a quantitative phosphoproteomic survey of induced pluripotent stem cell-derived AT2s (iAT2s) infected with SARS-CoV-2 at air-liquid interface (ALI). Time course analysis revealed rapid remodeling of diverse host systems, including signaling, RNA processing, translation, metabolism, nuclear integrity, protein trafficking, and cytoskeletal-microtubule organization, leading to cell cycle arrest, genotoxic stress, and innate immunity. Comparison to analogous data from transformed cell lines revealed respiratory-specific processes hijacked by SARS-CoV-2, highlighting potential novel therapeutic avenues that were validated by a high hit rate in a targeted small molecule screen in our iAT2 ALI system. |Alveolar Epithelial Cells/*metabolism/pathology/virology[MESH] |Animals[MESH] |Antiviral Agents[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/genetics/*metabolism/pathology[MESH] |Chlorocebus aethiops[MESH] |Cytopathogenic Effect, Viral[MESH] |Cytoskeleton[MESH] |Drug Evaluation, Preclinical[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/metabolism/pathology/virology[MESH] |Phosphoproteins/genetics/*metabolism[MESH] |Protein Transport[MESH] |Proteome/genetics/*metabolism[MESH] |SARS-CoV-2/genetics/*metabolism[MESH] |Signal Transduction[MESH]Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cell(epmc).pdf DeepDyve Pubget Overpricing