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10.1016/j.molcel.2020.11.004 http://scihub22266oqcxt.onion/10.1016/j.molcel.2020.11.004 33259809!7643667!33259809     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2020 ; 80 (6): 1067-1077.e5 Nephropedia Template TP {{tp|p=33259809|t=2020. The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2 |pdf=|usr=}}{{33259809}} gab.com Text The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2 JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=33259809 #FOAvip The Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA genomes in nature, coronaviruses are critically dependent on long-distance RNA-RNA interactions to regulate the viral transcription and replication pathways. Here we experimentally mapped the in vivo RNA-RNA interactome of the full-length SARS-CoV-2 genome and subgenomic mRNAs. We uncovered a network of RNA-RNA interactions spanning tens of thousands of nucleotides. These interactions reveal that the viral genome and subgenomes adopt alternative topologies inside cells and engage in different interactions with host RNAs. Notably, we discovered a long-range RNA-RNA interaction, the FSE-arch, that encircles the programmed ribosomal frameshifting element. The FSE-arch is conserved in the related MERS-CoV and is under purifying selection. Our findings illuminate RNA structure-based mechanisms governing replication, discontinuous transcription, and translation of coronaviruses and will aid future efforts to develop antiviral strategies. Twit Text FOAVip The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2 ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=33259809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33259809 #FOAvip English Wikipedia <ref>{{Cite pmid|33259809}}</ref> The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2 #MMPMID33259809 Ziv O; Price J; Shalamova L; Kamenova T; Goodfellow I; Weber F; Miska EA Mol Cell 2020[Dec]; 80 (6): 1067-1077.e5 PMID33259809show ga The Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA genomes in nature, coronaviruses are critically dependent on long-distance RNA-RNA interactions to regulate the viral transcription and replication pathways. Here we experimentally mapped the in vivo RNA-RNA interactome of the full-length SARS-CoV-2 genome and subgenomic mRNAs. We uncovered a network of RNA-RNA interactions spanning tens of thousands of nucleotides. These interactions reveal that the viral genome and subgenomes adopt alternative topologies inside cells and engage in different interactions with host RNAs. Notably, we discovered a long-range RNA-RNA interaction, the FSE-arch, that encircles the programmed ribosomal frameshifting element. The FSE-arch is conserved in the related MERS-CoV and is under purifying selection. Our findings illuminate RNA structure-based mechanisms governing replication, discontinuous transcription, and translation of coronaviruses and will aid future efforts to develop antiviral strategies. |*Frameshifting, Ribosomal[MESH] |Animals[MESH] |COVID-19/genetics/*metabolism[MESH] |Chlorocebus aethiops[MESH] |Genome, Viral/*physiology[MESH] |Humans[MESH] |Protein Biosynthesis[MESH] |RNA, Viral/*biosynthesis/genetics[MESH] |SARS-CoV-2/*physiology[MESH] |Transcription, Genetic[MESH] |Vero Cells[MESH]The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing