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10.1016/j.stem.2020.11.010 http://scihub22266oqcxt.onion/10.1016/j.stem.2020.11.010 33259798!7670932!33259798     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33259798&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell+Stem+Cell 2020 ; 27 (6): 869-875.e4 Nephropedia Template TP {{tp|p=33259798|t=2020. Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response |pdf=|usr=}}{{33259798}} gab.com Text Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=33259798 #FOAvip Current smoking is associated with increased risk of severe COVID-19, but it is not clear how cigarette smoke (CS) exposure affects SARS-CoV-2 airway cell infection. We directly exposed air-liquid interface (ALI) cultures derived from primary human nonsmoker airway basal stem cells (ABSCs) to short term CS and then infected them with SARS-CoV-2. We found an increase in the number of infected airway cells after CS exposure with a lack of ABSC proliferation. Single-cell profiling of the cultures showed that the normal interferon response was reduced after CS exposure with infection. Treatment of CS-exposed ALI cultures with interferon beta-1 abrogated the viral infection, suggesting one potential mechanism for more severe viral infection. Our data show that acute CS exposure allows for more severe airway epithelial disease from SARS-CoV-2 by reducing the innate immune response and ABSC proliferation and has implications for disease spread and severity in people exposed to CS. Twit Text FOAVip Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=33259798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33259798 #FOAvip English Wikipedia <ref>{{Cite pmid|33259798}}</ref> Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response #MMPMID33259798 Purkayastha A; Sen C; Garcia G Jr; Langerman J; Shia DW; Meneses LK; Vijayaraj P; Durra A; Koloff CR; Freund DR; Chi J; Rickabaugh TM; Mulay A; Konda B; Sim MS; Stripp BR; Plath K; Arumugaswami V; Gomperts BN Cell Stem Cell 2020[Dec]; 27 (6): 869-875.e4 PMID33259798show ga Current smoking is associated with increased risk of severe COVID-19, but it is not clear how cigarette smoke (CS) exposure affects SARS-CoV-2 airway cell infection. We directly exposed air-liquid interface (ALI) cultures derived from primary human nonsmoker airway basal stem cells (ABSCs) to short term CS and then infected them with SARS-CoV-2. We found an increase in the number of infected airway cells after CS exposure with a lack of ABSC proliferation. Single-cell profiling of the cultures showed that the normal interferon response was reduced after CS exposure with infection. Treatment of CS-exposed ALI cultures with interferon beta-1 abrogated the viral infection, suggesting one potential mechanism for more severe viral infection. Our data show that acute CS exposure allows for more severe airway epithelial disease from SARS-CoV-2 by reducing the innate immune response and ABSC proliferation and has implications for disease spread and severity in people exposed to CS. |COVID-19/genetics/immunology/*physiopathology/therapy[MESH] |Cells, Cultured[MESH] |Down-Regulation[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Interferon-beta/therapeutic use[MESH] |Patient Acuity[MESH] |Respiratory Mucosa/*physiopathology/virology[MESH] |Smoking/*adverse effects[MESH]Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection (epmc).pdf DeepDyve Pubget Overpricing