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10.1007/s00404-020-05889-5

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33258995!7706177!33258995
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suck abstract from ncbi


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pmid33258995      Arch+Gynecol+Obstet 2021 ; 303 (2): 337-345
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  • Clinical characteristics and outcomes of pregnant women with COVID-19 and the risk of vertical transmission: a systematic review #MMPMID33258995
  • Chi J; Gong W; Gao Q
  • Arch Gynecol Obstet 2021[Feb]; 303 (2): 337-345 PMID33258995show ga
  • PURPOSE: This systematic review summarizes the clinical features and maternal-infant outcomes of 230 pregnant women (154 patients gave birth) infected with COVID-19 and their 156 infants, including the possibility and evidence of vertical transmission. METHODS: An electronic search of PubMed, Embase, Medline, MedRxiv, CNKI, and the Chinese Medical Journal Full Text Database following PRISMA guidelines was performed through April 18, 2020. Search terms included COVID-19, SARS-CoV-2, pregnant women, infants, and vertical transmission. RESULTS: A total of 230 women with COVID-19 (154 deliveries, 66 ongoing pregnancies, and 10 abortions) and 156 newborns from 20 eligible studies were included in this systematic review. A total of 34.62% of the pregnant patients had obstetric complications, and 59.05% of patients displayed fever. Lymphopenia was observed in 40.71% of patients. A total of 5.19% of women received mechanical ventilation. Seven women were critically ill. One mother and two newborns died. A total of 24.74% of newborns were premature. Five newborns' throat swab tests of SARS-CoV-2 were positive, all of which were delivered by cesarean section. For eight newborns with negative throat swab tests, three had both elevated IgM and IgG against SARS-CoV-2. Nucleic acid tests of vaginal secretions, breast milk, amniotic fluid, placental blood, and placental tissues were negative. CONCLUSION: Most pregnant patients were mildly ill. The mortality of pregnant women with COVID-19 was lower than that of overall COVID-19 patients. Cesarean section was more common than vaginal delivery for pregnant women with COVID-19. Premature delivery was the main adverse event for newborns. The vertical transmission rate calculated by SARS-CoV-2 nucleic acid tests was 3.91%. Serum antibodies against SARS-CoV-2 should be tested more frequently, and multiple samples should be included in pathogenic testing.
  • |Abortion, Spontaneous[MESH]
  • |Adult[MESH]
  • |Amniotic Fluid[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Cesarean Section[MESH]
  • |Delivery, Obstetric/*statistics & numerical data[MESH]
  • |Female[MESH]
  • |Fever[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Infectious Disease Transmission, Vertical/*statistics & numerical data[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/*virology[MESH]
  • |Pregnant Women/*psychology[MESH]
  • |Premature Birth/virology[MESH]


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