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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Infect+Dis 2021 ; 223 (5): 802-804 Nephropedia Template TP
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Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance #MMPMID33257936
Klumpp-Thomas C; Kalish H; Hicks J; Mehalko J; Drew M; Memoli MJ; Hall MD; Esposito D; Sadtler K
J Infect Dis 2021[Mar]; 223 (5): 802-804 PMID33257936show ga
Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.