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10.1093/infdis/jiaa743

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa743
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33257936!7798976!33257936
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suck abstract from ncbi


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pmid33257936      J+Infect+Dis 2021 ; 223 (5): 802-804
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  • Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance #MMPMID33257936
  • Klumpp-Thomas C; Kalish H; Hicks J; Mehalko J; Drew M; Memoli MJ; Hall MD; Esposito D; Sadtler K
  • J Infect Dis 2021[Mar]; 223 (5): 802-804 PMID33257936show ga
  • Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.
  • |Antibodies, Viral/blood[MESH]
  • |COVID-19/*diagnosis/immunology/virology[MESH]
  • |Cross Reactions[MESH]
  • |Enzyme-Linked Immunosorbent Assay/methods[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A/*blood[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Immunoglobulin M/*blood[MESH]
  • |Mutation[MESH]
  • |SARS-CoV-2/classification/*immunology/pathogenicity[MESH]


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