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10.1038/s41467-020-19891-7 http://scihub22266oqcxt.onion/10.1038/s41467-020-19891-7 33257679!7705712!33257679     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33257679&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 6122 Nephropedia Template TP {{tp|p=33257679|t=2020. Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |pdf=|usr=}}{{33257679}} gab.com Text Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33257679 #FOAvip Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18 hACE2) represent a susceptible rodent model. K18 hACE2 transgenic mice succumbed to SARS-CoV-2 infection by day 6, with virus detected in lung airway epithelium and brain. K18 ACE2 transgenic mice produced a modest TH1/2/17 cytokine storm in the lung and spleen that peaked by day 2, and an extended chemokine storm that was detected in both lungs and brain. This chemokine storm was also detected in the brain at day 6. K18 hACE2 transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS-CoV-2 infection and associated severe COVID-19 disease. Twit Text FOAVip Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33257679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33257679 #FOAvip English Wikipedia <ref>{{Cite pmid|33257679}}</ref> Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice #MMPMID33257679 Oladunni FS; Park JG; Pino PA; Gonzalez O; Akhter A; Allue-Guardia A; Olmo-Fontanez A; Gautam S; Garcia-Vilanova A; Ye C; Chiem K; Headley C; Dwivedi V; Parodi LM; Alfson KJ; Staples HM; Schami A; Garcia JI; Whigham A; Platt RN 2nd; Gazi M; Martinez J; Chuba C; Earley S; Rodriguez OH; Mdaki SD; Kavelish KN; Escalona R; Hallam CRA; Christie C; Patterson JL; Anderson TJC; Carrion R Jr; Dick EJ Jr; Hall-Ursone S; Schlesinger LS; Alvarez X; Kaushal D; Giavedoni LD; Turner J; Martinez-Sobrido L; Torrelles JB Nat Commun 2020[Nov]; 11 (1): 6122 PMID33257679show ga Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18 hACE2) represent a susceptible rodent model. K18 hACE2 transgenic mice succumbed to SARS-CoV-2 infection by day 6, with virus detected in lung airway epithelium and brain. K18 ACE2 transgenic mice produced a modest TH1/2/17 cytokine storm in the lung and spleen that peaked by day 2, and an extended chemokine storm that was detected in both lungs and brain. This chemokine storm was also detected in the brain at day 6. K18 hACE2 transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS-CoV-2 infection and associated severe COVID-19 disease. |*Angiotensin-Converting Enzyme 2/genetics/immunology[MESH] |*COVID-19/immunology/pathology[MESH] |*Disease Models, Animal[MESH] |Animals[MESH] |Brain/immunology/pathology/virology[MESH] |Cytokine Release Syndrome/immunology/pathology[MESH] |Disease Susceptibility[MESH] |Genetic Predisposition to Disease[MESH] |Keratin-18/genetics[MESH] |Lung/immunology/pathology/virology[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Mortality[MESH] |Promoter Regions, Genetic/genetics[MESH] |Respiratory Mucosa/immunology/pathology/virology[MESH]Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting (epmc).pdf DeepDyve Pubget Overpricing