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10.1136/annrheumdis-2020-219279

http://scihub22266oqcxt.onion/10.1136/annrheumdis-2020-219279
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suck abstract from ncbi


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pmid33257496      Ann+Rheum+Dis 2021 ; 80 (5): 660-666
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  • Coronavirus disease 2019 outcomes among patients with rheumatic diseases 6 months into the pandemic #MMPMID33257496
  • Serling-Boyd N; D'Silva KM; Hsu TY; Wallwork R; Fu X; Gravallese EM; Jorge AM; Zhang Y; Choi H; Sparks JA; Wallace ZS
  • Ann Rheum Dis 2021[May]; 80 (5): 660-666 PMID33257496show ga
  • OBJECTIVE: In earlier studies, patients with rheumatic and musculoskeletal disease (RMD) who got infected with COVID-19 had a higher risk of mechanical ventilation than comparators. We sought to determine COVID-19 outcomes among patients with RMD 6 months into the pandemic. METHODS: We conducted a cohort study at Mass General Brigham in Boston, Massachusetts, of patients with RMD matched to up to five comparators by age, sex and COVID-19 diagnosis date (between 30 January 2020 and 16 July 2020) and followed until last encounter or 18 August 2020. COVID-19 outcomes were compared using Cox regression. Risk of mechanical ventilation was compared in an early versus a recent cohort of patients with RMD. RESULTS: We identified 143 patients with RMD and with COVID-19 (mean age 60 years; 76% female individuals) and 688 comparators (mean age 59 years; 76% female individuals). There were no significantly higher adjusted risks of hospitalisation (HR: 0.87, 95% CI: 0.68-1.11), intensive care unit admission (HR: 1.27, 95% CI: 0.86-1.86), or mortality (HR: 1.02, 95% CI: 0.53-1.95) in patients with RMD versus comparators. There was a trend towards a higher risk of mechanical ventilation in the RMD cohort versus comparators, although not statistically significant (adjusted HR: 1.51, 95% CI: 0.93-2.44). There was a trend towards improvement in mechanical ventilation risk in the recent versus early RMD cohort (10% vs 19%, adjusted HR: 0.44, 95% CI: 0.17-1.12). CONCLUSIONS: Patients with RMD and comparators had similar risks of poor COVID-19 outcomes after adjusting for race, smoking and comorbidities. The higher risk of mechanical ventilation in the early RMD cohort was no longer detected in a recent cohort, suggesting improved management over time.
  • |Aged[MESH]
  • |COVID-19/*complications[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Massachusetts[MESH]
  • |Middle Aged[MESH]
  • |Respiration, Artificial/statistics & numerical data[MESH]
  • |Rheumatic Diseases/*epidemiology[MESH]


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