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A Cell for the Ages: Human gammadelta T Cells across the Lifespan #MMPMID33255339
Clark BL; Thomas PG
Int J Mol Sci 2020[Nov]; 21 (23): ä PMID33255339show ga
The complexity of the human immune system is exacerbated by age-related changes to immune cell functionality. Many of these age-related effects remain undescribed or driven by mechanisms that are poorly understood. gammadelta T cells, while considered an adaptive subset based on immunological ontogeny, retain both innate-like and adaptive-like characteristics. This T cell population is small but mighty, and has been implicated in both homeostatic and disease-induced immunity within tissues and throughout the periphery. In this review, we outline what is known about the effect of age on human peripheral gammadelta T cells, and call attention to areas of the field where further research is needed.