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10.1016/j.mehy.2020.110231 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110231 33254538!7468676!33254538     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33254538&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Med+Hypotheses 2020 ; 144 (?): 110231 Nephropedia Template TP {{tp|p=33254538|t=2020. COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight?|pdf=|usr=}}{{33254538}} gab.com Text COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33254538 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has increased exponentially in numbers with more than 20 million people infected around the globe. It is clear that COVID-19 is not a simple viral pneumonia, but presents with unusual pathophysiological effects. Of special interest is that SARS-CoV-2 utilises the angiotensin-converting enzyme-2 (ACE2) for cell entry and therefore has a direct effect on the renin angiotensin system (RAS). The RAS is primarily responsible for blood pressure control via the classic pathway. Recently numerous other pathological processes have been described due to stimulation of this classic pathway. There is also a protective RAS pathway medicated by ACE2 which may be suppressed in COVID-19. This leads to overstimulation of the classic pathway with adverse cardiovascular and respiratory effects, hypercoagulation, endothelial dysfunction, inflammation and insulin resistance. We hypothesize that overreaction of the renin-angiotensin-aldosterone may account for the myriad of unusual biochemical and clinical abnormalities noted in patients infected with SARS-CoV-2. Twit Text FOAVip COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33254538 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33254538 #FOAvip English Wikipedia <ref>{{Cite pmid|33254538}}</ref> COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight? #MMPMID33254538 Wiese OJ; Allwood BW; Zemlin AE Med Hypotheses 2020[Nov]; 144 (?): 110231 PMID33254538show ga The coronavirus disease 2019 (COVID-19) pandemic has increased exponentially in numbers with more than 20 million people infected around the globe. It is clear that COVID-19 is not a simple viral pneumonia, but presents with unusual pathophysiological effects. Of special interest is that SARS-CoV-2 utilises the angiotensin-converting enzyme-2 (ACE2) for cell entry and therefore has a direct effect on the renin angiotensin system (RAS). The RAS is primarily responsible for blood pressure control via the classic pathway. Recently numerous other pathological processes have been described due to stimulation of this classic pathway. There is also a protective RAS pathway medicated by ACE2 which may be suppressed in COVID-19. This leads to overstimulation of the classic pathway with adverse cardiovascular and respiratory effects, hypercoagulation, endothelial dysfunction, inflammation and insulin resistance. We hypothesize that overreaction of the renin-angiotensin-aldosterone may account for the myriad of unusual biochemical and clinical abnormalities noted in patients infected with SARS-CoV-2. |*Gene Expression Regulation[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Blood Pressure[MESH] |COVID-19/complications/*metabolism/virology[MESH] |Cardiovascular Diseases/complications[MESH] |Critical Illness[MESH] |Cytokines/metabolism[MESH] |Female[MESH] |Humans[MESH] |Inflammation/*metabolism[MESH] |Insulin Resistance[MESH] |Intensive Care Units[MESH] |Male[MESH] |Models, Theoretical[MESH] |Obesity/complications[MESH] |Pandemics[MESH] |Renin-Angiotensin System/*physiology[MESH] |Respiratory Distress Syndrome/complications/virology[MESH] |SARS-CoV-2[MESH]COVID-19 and the renin-angiotensin system (RAS): A spark that sets the(epmc).pdf DeepDyve Pubget Overpricing