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Med Hypotheses 2020[Nov]; 144 (?): 110296 PMID33254487show ga
The factors that may contribute to a COVID-19 patient remaining in the asymptomatic stage, or to the infection evolving into the more serious stages are examined. In particular, we refer to the TMPRSS2 expression profile, balance of androgen and estrogen, blood group-A and/or B, nonsynonymous mutations in ORF3, and proteins NS7b and NS8 in SARS-CoV-2. Also, we review other factors related to the susceptibility and pathogenicity of SARS-CoV-2.
|*Asymptomatic Infections[MESH]
|*Genetic Predisposition to Disease[MESH]
|*SARS-CoV-2[MESH]
|Alleles[MESH]
|Androgens/metabolism[MESH]
|Angiotensin-Converting Enzyme 2/genetics[MESH]
|COVID-19/*genetics/virology[MESH]
|Coronavirus RNA-Dependent RNA Polymerase[MESH]
|Exome[MESH]
|Female[MESH]
|Gene Expression Profiling[MESH]
|Histocompatibility Antigens Class I/genetics[MESH]