Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1016/j.bpj.2020.11.2259

http://scihub22266oqcxt.onion/10.1016/j.bpj.2020.11.2259
suck pdf from google scholar
33253633!7695547!33253633
unlimited free pdf from europmc33253633    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi

pmid33253633      Biophys+J 2021 ; 120 (6): 1054-1059
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Thermal inactivation scaling applied for SARS-CoV-2 #MMPMID33253633
  • Seifer S; Elbaum M
  • Biophys J 2021[Mar]; 120 (6): 1054-1059 PMID33253633show ga
  • Based on a model of protein denaturation rate limited by an entropy-related barrier, we derive a simple formula for virus inactivation time as a function of temperature. Loss of protein structure is described by two reaction coordinates: conformational disorder of the polymer and wetting by the solvent. These establish a competition between conformational entropy and hydrophobic interaction favoring random coil or globular states, respectively. Based on the Landau theory of phase transition, the resulting free energy barrier is found to decrease linearly with the temperature difference T - T(m), and the inactivation rate should scale as U to the power of T - T(m). This form recalls an accepted model of thermal damage to cells in hyperthermia. For SARS-CoV-2 the value of U in Celsius units is found to be 1.32. Although the fitting of the model to measured data is practically indistinguishable from Arrhenius law with an activation energy, the entropy barrier mechanism is more suitable and could explain the pronounced sensitivity of SARS-CoV-2 to thermal damage. Accordingly, we predict the efficacy of mild fever over a period of approximately 24 h in inactivating the virus.
  • |*Temperature[MESH]
  • |*Virus Inactivation[MESH]
  • |COVID-19/complications[MESH]
  • |Fever/virology[MESH]
  • |Humans[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box