Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1080/22221751.2020.1858177 http://scihub22266oqcxt.onion/10.1080/22221751.2020.1858177 33251966!7782266!33251966     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2020 ; 9 (1): 2673-2684 Nephropedia Template TP {{tp|p=33251966|t=2020. Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection |pdf=|usr=}}{{33251966}} gab.com Text Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33251966 #FOAvip Following emergence in late 2019, SARS-CoV-2 rapidly became pandemic and is presently responsible for millions of infections and hundreds of thousands of deaths worldwide. There is currently no approved vaccine to halt the spread of SARS-CoV-2 and only very few treatment options are available to manage COVID-19 patients. For development of preclinical countermeasures, reliable and well-characterized small animal disease models will be of paramount importance. Here we show that intranasal inoculation of SARS-CoV-2 into Syrian hamsters consistently caused moderate broncho-interstitial pneumonia, with high viral lung loads and extensive virus shedding, but animals only displayed transient mild disease. We determined the infectious dose 50 to be only five infectious particles, making the Syrian hamster a highly susceptible model for SARS-CoV-2 infection. Neither hamster age nor sex had any impact on the severity of disease or course of infection. Finally, prolonged viral persistence in interleukin 2 receptor gamma chain knockout hamsters revealed susceptibility of SARS-CoV-2 to adaptive immune control. In conclusion, the Syrian hamster is highly susceptible to SARS-CoV-2 making it a very suitable infection model for COVID-19 countermeasure development. Twit Text FOAVip Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33251966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33251966 #FOAvip English Wikipedia <ref>{{Cite pmid|33251966}}</ref> Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection #MMPMID33251966 Rosenke K; Meade-White K; Letko M; Clancy C; Hansen F; Liu Y; Okumura A; Tang-Huau TL; Li R; Saturday G; Feldmann F; Scott D; Wang Z; Munster V; Jarvis MA; Feldmann H Emerg Microbes Infect 2020[Dec]; 9 (1): 2673-2684 PMID33251966show ga Following emergence in late 2019, SARS-CoV-2 rapidly became pandemic and is presently responsible for millions of infections and hundreds of thousands of deaths worldwide. There is currently no approved vaccine to halt the spread of SARS-CoV-2 and only very few treatment options are available to manage COVID-19 patients. For development of preclinical countermeasures, reliable and well-characterized small animal disease models will be of paramount importance. Here we show that intranasal inoculation of SARS-CoV-2 into Syrian hamsters consistently caused moderate broncho-interstitial pneumonia, with high viral lung loads and extensive virus shedding, but animals only displayed transient mild disease. We determined the infectious dose 50 to be only five infectious particles, making the Syrian hamster a highly susceptible model for SARS-CoV-2 infection. Neither hamster age nor sex had any impact on the severity of disease or course of infection. Finally, prolonged viral persistence in interleukin 2 receptor gamma chain knockout hamsters revealed susceptibility of SARS-CoV-2 to adaptive immune control. In conclusion, the Syrian hamster is highly susceptible to SARS-CoV-2 making it a very suitable infection model for COVID-19 countermeasure development. |*Disease Models, Animal[MESH] |*SARS-CoV-2[MESH] |Animals[MESH] |COVID-19/*etiology/immunology/pathology[MESH] |Chlorocebus aethiops[MESH] |Cricetinae[MESH] |Disease Susceptibility[MESH] |Female[MESH] |Lung/pathology[MESH] |Male[MESH] |Mesocricetus[MESH] |RNA, Viral/analysis[MESH] |Receptors, Interleukin-2/physiology[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]Defining the Syrian hamster as a highly susceptible preclinical model (epmc).pdf DeepDyve Pubget Overpricing