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10.1002/eji.202048858 http://scihub22266oqcxt.onion/10.1002/eji.202048858 33251605!7753288!33251605     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2021 ; 51 (3): 634-647 Nephropedia Template TP {{tp|p=33251605|t=2021. Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19 patients |pdf=|usr=}}{{33251605}} gab.com Text Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19 patients JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33251605 #FOAvip SARS-CoV-2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID-19. We investigated whether the specific immune responses in the peripheral blood of 276 patients were associated with the severity and progression of COVID-19. At admission, dramatic lymphopenia of T, B, and NK cells is associated with severity. Conversely, the proportion of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56(-) CD16(+) NK-cells increased. Regarding humoral immunity, levels of IgM, IgA, and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients. Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless of their severity. Moreover, total IgG, the IgG1 and IgG3 isotypes, and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. Our study provides important clues to understand the immune response observed in COVID-19 patients, associating severity with an imbalanced humoral response, and identifying new targets for therapeutic intervention. Twit Text FOAVip Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19 patients ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33251605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33251605 #FOAvip English Wikipedia <ref>{{Cite pmid|33251605}}</ref> Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19 patients #MMPMID33251605 Marcos-Jimenez A; Sanchez-Alonso S; Alcaraz-Serna A; Esparcia L; Lopez-Sanz C; Sampedro-Nunez M; Mateu-Albero T; Sanchez-Cerrillo I; Martinez-Fleta P; Gabrie L; Del Campo Guerola L; Rodriguez-Frade JM; Casasnovas JM; Reyburn HT; Vales-Gomez M; Lopez-Trascasa M; Martin-Gayo E; Calzada MJ; Castaneda S; de la Fuente H; Gonzalez-Alvaro I; Sanchez-Madrid F; Munoz-Calleja C; Alfranca A Eur J Immunol 2021[Mar]; 51 (3): 634-647 PMID33251605show ga SARS-CoV-2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID-19. We investigated whether the specific immune responses in the peripheral blood of 276 patients were associated with the severity and progression of COVID-19. At admission, dramatic lymphopenia of T, B, and NK cells is associated with severity. Conversely, the proportion of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56(-) CD16(+) NK-cells increased. Regarding humoral immunity, levels of IgM, IgA, and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients. Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless of their severity. Moreover, total IgG, the IgG1 and IgG3 isotypes, and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. Our study provides important clues to understand the immune response observed in COVID-19 patients, associating severity with an imbalanced humoral response, and identifying new targets for therapeutic intervention. |Aged[MESH] |B-Lymphocytes/*immunology[MESH] |COVID-19/immunology/*pathology[MESH] |Complement C3/analysis[MESH] |Complement C4/analysis[MESH] |Complement C5/analysis[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/blood[MESH] |Immunoglobulin G/blood[MESH] |Immunoglobulin M/blood[MESH] |Immunoglobulins/*blood[MESH] |Killer Cells, Natural/*immunology[MESH] |Lymphocyte Count[MESH] |Lymphopenia/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Respiratory Distress Syndrome/immunology/pathology[MESH] |SARS-CoV-2/*immunology[MESH]Deregulated cellular circuits driving immunoglobulins and complement c(epmc).pdf DeepDyve Pubget Overpricing