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10.3389/fcimb.2020.561502 http://scihub22266oqcxt.onion/10.3389/fcimb.2020.561502 33251157!7671970!33251157     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Infect+Microbiol 2020 ; 10 (ä): 561502 Nephropedia Template TP {{tp|p=33251157|t=2020. Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture |pdf=|usr=}}{{33251157}} gab.com Text Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture JO: Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33251157 #FOAvip Andes virus (ANDV) and Sin Nombre virus (SNV), highly pathogenic hantaviruses, cause hantavirus pulmonary syndrome in the Americas. Currently no therapeutics are approved for use against these infections. Griffithsin (GRFT) is a high-mannose oligosaccharide-binding lectin currently being evaluated in phase I clinical trials as a topical microbicide for the prevention of human immunodeficiency virus (HIV-1) infection (ClinicalTrials.gov Identifiers: NCT04032717, NCT02875119) and has shown broad-spectrum in vivo activity against other viruses, including severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, and Nipah virus. In this study, we evaluated the in vitro antiviral activity of GRFT and its synthetic trimeric tandemer 3mGRFT against ANDV and SNV. Our results demonstrate that GRFT is a potent inhibitor of ANDV infection. GRFT inhibited entry of pseudo-particles typed with ANDV envelope glycoprotein into host cells, suggesting that it inhibits viral envelope protein function during entry. 3mGRFT is more potent than GRFT against ANDV and SNV infection. Our results warrant the testing of GRFT and 3mGRFT against ANDV infection in animal models. Twit Text FOAVip Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture ????Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33251157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33251157 #FOAvip English Wikipedia <ref>{{Cite pmid|33251157}}</ref> Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture #MMPMID33251157 Shrivastava-Ranjan P; Lo MK; Chatterjee P; Flint M; Nichol ST; Montgomery JM; O'Keefe BR; Spiropoulou CF Front Cell Infect Microbiol 2020[]; 10 (ä): 561502 PMID33251157show ga Andes virus (ANDV) and Sin Nombre virus (SNV), highly pathogenic hantaviruses, cause hantavirus pulmonary syndrome in the Americas. Currently no therapeutics are approved for use against these infections. Griffithsin (GRFT) is a high-mannose oligosaccharide-binding lectin currently being evaluated in phase I clinical trials as a topical microbicide for the prevention of human immunodeficiency virus (HIV-1) infection (ClinicalTrials.gov Identifiers: NCT04032717, NCT02875119) and has shown broad-spectrum in vivo activity against other viruses, including severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, and Nipah virus. In this study, we evaluated the in vitro antiviral activity of GRFT and its synthetic trimeric tandemer 3mGRFT against ANDV and SNV. Our results demonstrate that GRFT is a potent inhibitor of ANDV infection. GRFT inhibited entry of pseudo-particles typed with ANDV envelope glycoprotein into host cells, suggesting that it inhibits viral envelope protein function during entry. 3mGRFT is more potent than GRFT against ANDV and SNV infection. Our results warrant the testing of GRFT and 3mGRFT against ANDV infection in animal models. |Antiviral Agents/*pharmacology[MESH] |Cell Culture Techniques[MESH] |Cell Line[MESH] |Hantavirus Pulmonary Syndrome/drug therapy/*virology[MESH] |Humans[MESH] |Lectins/*pharmacology[MESH] |Orthohantavirus/*drug effects/physiology[MESH]Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture (epmc).pdf DeepDyve Pubget Overpricing