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10.1111/nan.12677 http://scihub22266oqcxt.onion/10.1111/nan.12677 33249605!7753688!33249605     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuropathol+Appl+Neurobiol 2021 ; 47 (3): 454-459 Nephropedia Template TP {{tp|p=33249605|t=2021. Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19 |pdf=|usr=}}{{33249605}} gab.com Text Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19 JO: Neuropathol Appl Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=33249605 #FOAvip Coronavirus disease 19 (COVID-19) is a rapidly evolving pandemic caused by the coronavirus Sars-CoV-2. Clinically manifest central nervous system symptoms have been described in COVID-19 patients and could be the consequence of commonly associated vascular pathology, but the detailed neuropathological sequelae remain largely unknown. A total of six cases, all positive for Sars-CoV-2, showed evidence of cerebral petechial hemorrhages and microthrombi at autopsy. Two out of six patients showed an elevated risk for disseminated intravascular coagulopathy according to current criteria and were excluded from further analysis. In the remaining four patients, the hemorrhages were most prominent at the grey and white matter junction of the neocortex, but were also found in the brainstem, deep grey matter structures and cerebellum. Two patients showed vascular intramural inflammatory infiltrates, consistent with Sars-CoV-2-associated endotheliitis, which was associated by elevated levels of the Sars-CoV-2 receptor ACE2 in the brain vasculature. Distribution and morphology of patchy brain microbleeds was clearly distinct from hypertension-related hemorrhage, critical illness-associated microbleeds and cerebral amyloid angiopathy, which was ruled out by immunohistochemistry. Cerebral microhemorrhages in COVID-19 patients could be a consequence of Sars- CoV-2-induced endotheliitis and more general vasculopathic changes and may correlate with an increased risk of vascular encephalopathy. Twit Text FOAVip Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19 ????Neuropathol Appl Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=33249605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33249605 #FOAvip English Wikipedia <ref>{{Cite pmid|33249605}}</ref> Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19 #MMPMID33249605 Kirschenbaum D; Imbach LL; Rushing EJ; Frauenknecht KBM; Gascho D; Ineichen BV; Keller E; Kohler S; Lichtblau M; Reimann RR; Schreib K; Ulrich S; Steiger P; Aguzzi A; Frontzek K Neuropathol Appl Neurobiol 2021[Apr]; 47 (3): 454-459 PMID33249605show ga Coronavirus disease 19 (COVID-19) is a rapidly evolving pandemic caused by the coronavirus Sars-CoV-2. Clinically manifest central nervous system symptoms have been described in COVID-19 patients and could be the consequence of commonly associated vascular pathology, but the detailed neuropathological sequelae remain largely unknown. A total of six cases, all positive for Sars-CoV-2, showed evidence of cerebral petechial hemorrhages and microthrombi at autopsy. Two out of six patients showed an elevated risk for disseminated intravascular coagulopathy according to current criteria and were excluded from further analysis. In the remaining four patients, the hemorrhages were most prominent at the grey and white matter junction of the neocortex, but were also found in the brainstem, deep grey matter structures and cerebellum. Two patients showed vascular intramural inflammatory infiltrates, consistent with Sars-CoV-2-associated endotheliitis, which was associated by elevated levels of the Sars-CoV-2 receptor ACE2 in the brain vasculature. Distribution and morphology of patchy brain microbleeds was clearly distinct from hypertension-related hemorrhage, critical illness-associated microbleeds and cerebral amyloid angiopathy, which was ruled out by immunohistochemistry. Cerebral microhemorrhages in COVID-19 patients could be a consequence of Sars- CoV-2-induced endotheliitis and more general vasculopathic changes and may correlate with an increased risk of vascular encephalopathy. |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*complications[MESH] |Cerebral Hemorrhage/*pathology/*virology[MESH] |Endothelial Cells/pathology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Intracerebral endotheliitis and microbleeds are neuropathological feat(epmc).pdf DeepDyve Pubget Overpricing