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10.1016/j.pdpdt.2020.102112 http://scihub22266oqcxt.onion/10.1016/j.pdpdt.2020.102112 33249118!7690324!33249118     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Photodiagnosis+Photodyn+Ther 2021 ; 33 (ä): 102112 Nephropedia Template TP {{tp|p=33249118|t=2021. Antiviral photodynamic therapy: Inactivation and inhibition of SARS-CoV-2 in vitro using methylene blue and Radachlorin |pdf=|usr=}}{{33249118}} gab.com Text Antiviral photodynamic therapy: Inactivation and inhibition of SARS-CoV-2 in vitro using methylene blue and Radachlorin JO: Photodiagnosis Photodyn Ther http://www.kidney.de/pget.php?&tw=1&pmid=33249118 #FOAvip INTRODUCTION: Recently, the COVID-19 pandemic has spread globally, necessitating the development of new methods for its prevention and treatment. The purpose of this study was to evaluate the antiviral activity of photodynamic therapy (PDT) against SARS-CoV-2 in vitro. METHODS: Vero E6 cells and SARS-CoV-2 isolated in Russia were used for PDT with methylene blue (MB) and Radachlorin. A continuous laser with wavelength lambda = 662 nm in doses of 16 J/cm(2) and 40 J/cm(2) laser irradiation was used for PDT of a viral suspension and SARS-CoV-2-infected cells. The direct cytopathogenic effect of SARS-CoV-2 was evaluated via light microscopy to calculate the TCID(50) in the samples and perform statistical analysis. RESULTS: Viral suspensions of SARS-CoV-2 that had a TCID(50) greater than 10(3) were inactivated by PDT in the presence of MB and Radachlorin. Vero E6 cells were protected from 10(4) TCID(50) of SARS-CoV-2 by PDT post infection. The range of protective concentrations was 1.0-10.0 mug/ml and 0.5-5.0 mug/ml for MB and Radachlorin, respectively. Additionally, it was found that MB and Radachlorin also possess significant antiviral activity even without PDT. The 50 % inhibitory concentration (IC(50)) against 10(2) TCID(50) of SARS-CoV-2 was found to be 0.22 and 0.33 mug/mL with the addition of MB and Radachlorin, respectively, to cells concomitantly with virus, whereas in the case of applying the photosensitizers at 3.5 h post infection, the IC(50) was 0.6 and 2.0 mug/mL for MB and Radachlorin, respectively. CONCLUSION: PDT shows high antiviral activity against SARS-CoV-2 when combined with MB and Radachlorin in vitro. Twit Text FOAVip Antiviral photodynamic therapy: Inactivation and inhibition of SARS-CoV-2 in vitro using methylene blue and Radachlorin ????Photodiagnosis Photodyn Ther http://www.kidney.de/pget.php?&tw=1&pmid=33249118 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33249118 #FOAvip English Wikipedia <ref>{{Cite pmid|33249118}}</ref> Antiviral photodynamic therapy: Inactivation and inhibition of SARS-CoV-2 in vitro using methylene blue and Radachlorin #MMPMID33249118 Svyatchenko VA; Nikonov SD; Mayorov AP; Gelfond ML; Loktev VB Photodiagnosis Photodyn Ther 2021[Mar]; 33 (ä): 102112 PMID33249118show ga INTRODUCTION: Recently, the COVID-19 pandemic has spread globally, necessitating the development of new methods for its prevention and treatment. The purpose of this study was to evaluate the antiviral activity of photodynamic therapy (PDT) against SARS-CoV-2 in vitro. METHODS: Vero E6 cells and SARS-CoV-2 isolated in Russia were used for PDT with methylene blue (MB) and Radachlorin. A continuous laser with wavelength lambda = 662 nm in doses of 16 J/cm(2) and 40 J/cm(2) laser irradiation was used for PDT of a viral suspension and SARS-CoV-2-infected cells. The direct cytopathogenic effect of SARS-CoV-2 was evaluated via light microscopy to calculate the TCID(50) in the samples and perform statistical analysis. RESULTS: Viral suspensions of SARS-CoV-2 that had a TCID(50) greater than 10(3) were inactivated by PDT in the presence of MB and Radachlorin. Vero E6 cells were protected from 10(4) TCID(50) of SARS-CoV-2 by PDT post infection. The range of protective concentrations was 1.0-10.0 mug/ml and 0.5-5.0 mug/ml for MB and Radachlorin, respectively. Additionally, it was found that MB and Radachlorin also possess significant antiviral activity even without PDT. The 50 % inhibitory concentration (IC(50)) against 10(2) TCID(50) of SARS-CoV-2 was found to be 0.22 and 0.33 mug/mL with the addition of MB and Radachlorin, respectively, to cells concomitantly with virus, whereas in the case of applying the photosensitizers at 3.5 h post infection, the IC(50) was 0.6 and 2.0 mug/mL for MB and Radachlorin, respectively. CONCLUSION: PDT shows high antiviral activity against SARS-CoV-2 when combined with MB and Radachlorin in vitro. |Animals[MESH] |Chlorocebus aethiops[MESH] |Dose-Response Relationship, Drug[MESH] |Drug Combinations[MESH] |Methylene Blue/*pharmacology[MESH] |Microbiological Techniques[MESH] |Photochemotherapy/*methods[MESH] |Photosensitizing Agents/*pharmacology[MESH] |Porphyrins[MESH] |SARS-CoV-2/*drug effects[MESH]Antiviral photodynamic therapy: Inactivation and inhibition of SARS-Co(epmc).pdf DeepDyve Pubget Overpricing