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10.1016/j.bbrc.2020.11.041 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2020.11.041 33248689!7676326!33248689     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2021 ; 538 (ä): 40-46 Nephropedia Template TP {{tp|p=33248689|t=2021. Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics |pdf=|usr=}}{{33248689}} gab.com Text Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33248689 #FOAvip The impact of COVID-19 on public health and the global economy has led to an unprecedented research response, with a major emphasis on the development of safe vaccines and drugs. However, effective, safe treatments typically take over a decade to develop and there are still no clinically approved therapies to treat highly pathogenic coronaviruses. Repurposing of known drugs can speed up development and this strategy, along with the use of biologicals (notably monoclonal antibody therapy) and vaccine development programmes remain the principal routes to dealing with the immediate impact of COVID-19. Nevertheless, the development of broadly-effective highly potent antivirals should be a major longer term goal. Structural biology has been applied with enormous effect, with key proteins structurally characterised only weeks after the SARS-CoV-2 sequence was released. Open-access to advanced infrastructure for structural biology techniques at synchrotrons and high-end cryo-EM and NMR centres has brought these technologies centre-stage in drug discovery. We summarise the role of Diamond Light Source in responses to the pandemic and note the impact of the immediate release of results in fuelling an open-science approach to early-stage drug discovery. Twit Text FOAVip Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33248689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33248689 #FOAvip English Wikipedia <ref>{{Cite pmid|33248689}}</ref> Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics #MMPMID33248689 Walsh MA; Grimes JM; Stuart DI Biochem Biophys Res Commun 2021[Jan]; 538 (ä): 40-46 PMID33248689show ga The impact of COVID-19 on public health and the global economy has led to an unprecedented research response, with a major emphasis on the development of safe vaccines and drugs. However, effective, safe treatments typically take over a decade to develop and there are still no clinically approved therapies to treat highly pathogenic coronaviruses. Repurposing of known drugs can speed up development and this strategy, along with the use of biologicals (notably monoclonal antibody therapy) and vaccine development programmes remain the principal routes to dealing with the immediate impact of COVID-19. Nevertheless, the development of broadly-effective highly potent antivirals should be a major longer term goal. Structural biology has been applied with enormous effect, with key proteins structurally characterised only weeks after the SARS-CoV-2 sequence was released. Open-access to advanced infrastructure for structural biology techniques at synchrotrons and high-end cryo-EM and NMR centres has brought these technologies centre-stage in drug discovery. We summarise the role of Diamond Light Source in responses to the pandemic and note the impact of the immediate release of results in fuelling an open-science approach to early-stage drug discovery. |*COVID-19 Drug Treatment[MESH] |*Drug Development[MESH] |*Drug Discovery[MESH] |*SARS-CoV-2/genetics/metabolism[MESH] |*Viral Proteins/chemistry/genetics[MESH] |Humans[MESH]Diamond Light Source: contributions to SARS-CoV-2 biology and therapeu(epmc).pdf DeepDyve Pubget Overpricing