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10.1016/j.antiviral.2020.104988 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2020.104988 33248195!7687369!33248195     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2021 ; 185 (ä): 104988 Nephropedia Template TP {{tp|p=33248195|t=2021. Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro |pdf=|usr=}}{{33248195}} gab.com Text Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=33248195 #FOAvip Pandemic spread of emerging human pathogenic viruses, such as the current SARS-CoV-2, poses both an immediate and future challenge to human health and society. Currently, effective treatment of infection with SARS-CoV-2 is limited and broad spectrum antiviral therapies to meet other emerging pandemics are absent leaving the World population largely unprotected. Here, we have identified distinct members of the family of polyether ionophore antibiotics with potent ability to inhibit SARS-CoV-2 replication and cytopathogenicity in cells. Several compounds from this class displayed more than 100-fold selectivity between viral-induced cytopathogenicity and inhibition of cell viability, however the compound X-206 displayed >500-fold selectivity and was furthermore able to inhibit viral replication even at sub-nM levels. The antiviral mechanism of the polyether ionophores is currently not understood in detail. We demonstrate, e.g. through unbiased bioactivity profiling, that their effects on the host cells differ from those of cationic amphiphiles such as hydroxychloroquine. Collectively, our data suggest that polyether ionophore antibiotics should be subject to further investigations as potential broad-spectrum antiviral agents. Twit Text FOAVip Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=33248195 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33248195 #FOAvip English Wikipedia <ref>{{Cite pmid|33248195}}</ref> Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro #MMPMID33248195 Svenningsen EB; Thyrsted J; Blay-Cadanet J; Liu H; Lin S; Moyano-Villameriel J; Olagnier D; Idorn M; Paludan SR; Holm CK; Poulsen TB Antiviral Res 2021[Jan]; 185 (ä): 104988 PMID33248195show ga Pandemic spread of emerging human pathogenic viruses, such as the current SARS-CoV-2, poses both an immediate and future challenge to human health and society. Currently, effective treatment of infection with SARS-CoV-2 is limited and broad spectrum antiviral therapies to meet other emerging pandemics are absent leaving the World population largely unprotected. Here, we have identified distinct members of the family of polyether ionophore antibiotics with potent ability to inhibit SARS-CoV-2 replication and cytopathogenicity in cells. Several compounds from this class displayed more than 100-fold selectivity between viral-induced cytopathogenicity and inhibition of cell viability, however the compound X-206 displayed >500-fold selectivity and was furthermore able to inhibit viral replication even at sub-nM levels. The antiviral mechanism of the polyether ionophores is currently not understood in detail. We demonstrate, e.g. through unbiased bioactivity profiling, that their effects on the host cells differ from those of cationic amphiphiles such as hydroxychloroquine. Collectively, our data suggest that polyether ionophore antibiotics should be subject to further investigations as potential broad-spectrum antiviral agents. |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |Anti-Bacterial Agents/*pharmacology[MESH] |Antiviral Agents/*pharmacology[MESH] |Chlorocebus aethiops[MESH] |Ethers, Cyclic/*pharmacology[MESH] |Humans[MESH] |Ionophores/*pharmacology[MESH] |SARS-CoV-2/*drug effects[MESH] |Vero Cells[MESH]Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infecti(epmc).pdf DeepDyve Pubget Overpricing