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10.1038/s41467-020-19943-y

http://scihub22266oqcxt.onion/10.1038/s41467-020-19943-y
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33247152!7699636!33247152
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suck abstract from ncbi


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pmid33247152      Nat+Commun 2020 ; 11 (1): 6044
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  • Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19 #MMPMID33247152
  • Li K; Huang B; Wu M; Zhong A; Li L; Cai Y; Wang Z; Wu L; Zhu M; Li J; Wang Z; Wu W; Li W; Bosco B; Gan Z; Qiao Q; Wu J; Wang Q; Wang S; Xia X
  • Nat Commun 2020[Nov]; 11 (1): 6044 PMID33247152show ga
  • Deciphering the dynamic changes in antibodies against SARS-CoV-2 is essential for understanding the immune response in COVID-19 patients. Here we analyze the laboratory findings of 1,850 patients to describe the dynamic changes of the total antibody, spike protein (S)-, receptor-binding domain (RBD)-, and nucleoprotein (N)-specific immunoglobulin M (IgM) and G (IgG) levels during SARS-CoV-2 infection and recovery. The generation of S-, RBD-, and N-specific IgG occurs one week later in patients with severe/critical COVID-19 compared to patients with mild/moderate disease, while S- and RBD-specific IgG levels are 1.5-fold higher in severe/critical patients during hospitalization. The RBD-specific IgG levels are 4-fold higher in older patients than in younger patients during hospitalization. In addition, the S- and RBD-specific IgG levels are 2-fold higher in the recovered patients who are SARS-CoV-2 RNA negative than those who are RNA positive. Lower S-, RBD-, and N-specific IgG levels are associated with a lower lymphocyte percentage, higher neutrophil percentage, and a longer duration of viral shedding. Patients with low antibody levels on discharge might thereby have a high chance of being tested positive for SARS-CoV-2 RNA after recovery. Our study provides important information for COVID-19 diagnosis, treatment, and vaccine development.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Viral/*blood/immunology[MESH]
  • |COVID-19 Testing/methods/statistics & numerical data[MESH]
  • |COVID-19/blood/diagnosis/*immunology/mortality[MESH]
  • |Child[MESH]
  • |Coronavirus Nucleocapsid Proteins/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood/immunology[MESH]
  • |Immunoglobulin M/blood/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Protein Domains/immunology[MESH]
  • |RNA, Viral/isolation & purification[MESH]
  • |SARS-CoV-2/genetics/*immunology/isolation & purification[MESH]
  • |Severity of Illness Index[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]
  • |Survivors/statistics & numerical data[MESH]
  • |Virus Shedding/immunology[MESH]


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