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10.1038/s41467-020-19967-4 http://scihub22266oqcxt.onion/10.1038/s41467-020-19967-4 33247138!7695721!33247138     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 6078 Nephropedia Template TP {{tp|p=33247138|t=2020. Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates |pdf=|usr=}}{{33247138}} gab.com Text Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33247138 #FOAvip Understanding SARS-CoV-2 associated immune pathology is crucial to develop pan-effective vaccines and treatments. Here we investigate the immune events from the acute state up to four weeks post SARS-CoV-2 infection, in non-human primates (NHP) with heterogeneous pulmonary pathology. We show a robust migration of CD16 expressing monocytes to the lungs occurring during the acute phase, and we describe two subsets of interstitial macrophages (HLA-DR(+)CD206(-)): a transitional CD11c(+)CD16(+) cell population directly associated with IL-6 levels in plasma, and a long-lasting CD11b(+)CD16(+) cell population. Trafficking of monocytes is mediated by TARC (CCL17) and associates with viral load measured in bronchial brushes. We also describe associations between disease outcomes and high levels of cell infiltration in lungs including CD11b(+)CD16(hi) macrophages and CD11b(+) neutrophils. Accumulation of macrophages is long-lasting and detectable even in animals with mild or no signs of disease. Interestingly, animals with anti-inflammatory responses including high IL-10:IL-6 and kynurenine to tryptophan ratios show less severe illness. Our results unravel cellular mechanisms of COVID-19 and suggest that NHP may be appropriate models to test immune therapies. Twit Text FOAVip Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33247138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33247138 #FOAvip English Wikipedia <ref>{{Cite pmid|33247138}}</ref> Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates #MMPMID33247138 Fahlberg MD; Blair RV; Doyle-Meyers LA; Midkiff CC; Zenere G; Russell-Lodrigue KE; Monjure CJ; Haupt EH; Penney TP; Lehmicke G; Threeton BM; Golden N; Datta PK; Roy CJ; Bohm RP; Maness NJ; Fischer T; Rappaport J; Vaccari M Nat Commun 2020[Nov]; 11 (1): 6078 PMID33247138show ga Understanding SARS-CoV-2 associated immune pathology is crucial to develop pan-effective vaccines and treatments. Here we investigate the immune events from the acute state up to four weeks post SARS-CoV-2 infection, in non-human primates (NHP) with heterogeneous pulmonary pathology. We show a robust migration of CD16 expressing monocytes to the lungs occurring during the acute phase, and we describe two subsets of interstitial macrophages (HLA-DR(+)CD206(-)): a transitional CD11c(+)CD16(+) cell population directly associated with IL-6 levels in plasma, and a long-lasting CD11b(+)CD16(+) cell population. Trafficking of monocytes is mediated by TARC (CCL17) and associates with viral load measured in bronchial brushes. We also describe associations between disease outcomes and high levels of cell infiltration in lungs including CD11b(+)CD16(hi) macrophages and CD11b(+) neutrophils. Accumulation of macrophages is long-lasting and detectable even in animals with mild or no signs of disease. Interestingly, animals with anti-inflammatory responses including high IL-10:IL-6 and kynurenine to tryptophan ratios show less severe illness. Our results unravel cellular mechanisms of COVID-19 and suggest that NHP may be appropriate models to test immune therapies. |*Disease Models, Animal[MESH] |Acute Disease[MESH] |Animals[MESH] |COVID-19/diagnosis/*immunology/pathology/virology[MESH] |Cytokines/metabolism[MESH] |Disease Progression[MESH] |Female[MESH] |Humans[MESH] |Lung/cytology/*immunology/virology[MESH] |Macaca mulatta/immunology/virology[MESH] |Macrophages/immunology[MESH] |Male[MESH] |Monocytes/immunology/metabolism[MESH] |Neutrophils/immunology/metabolism[MESH] |SARS-CoV-2/*immunology/isolation & purification[MESH] |Severity of Illness Index[MESH] |Viral Load/immunology[MESH]Cellular events of acute, resolving or progressive COVID-19 in SARS-Co(epmc).pdf DeepDyve Pubget Overpricing