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10.1038/s41467-020-19883-7 http://scihub22266oqcxt.onion/10.1038/s41467-020-19883-7 33247099!7695715!33247099     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 6059 Nephropedia Template TP {{tp|p=33247099|t=2020. SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication |pdf=|usr=}}{{33247099}} gab.com Text SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33247099 #FOAvip Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first detected in late December 2019 and has spread worldwide. Coronaviruses are enveloped, positive sense, single-stranded RNA viruses and employ a complicated pattern of virus genome length RNA replication as well as transcription of genome length and leader containing subgenomic RNAs. Although not fully understood, both replication and transcription are thought to take place in so-called double-membrane vesicles in the cytoplasm of infected cells. Here we show detection of SARS-CoV-2 subgenomic RNAs in diagnostic samples up to 17 days after initial detection of infection and provide evidence for their nuclease resistance and protection by cellular membranes suggesting that detection of subgenomic RNAs in such samples may not be a suitable indicator of active coronavirus replication/infection. Twit Text FOAVip SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33247099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33247099 #FOAvip English Wikipedia <ref>{{Cite pmid|33247099}}</ref> SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication #MMPMID33247099 Alexandersen S; Chamings A; Bhatta TR Nat Commun 2020[Nov]; 11 (1): 6059 PMID33247099show ga Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first detected in late December 2019 and has spread worldwide. Coronaviruses are enveloped, positive sense, single-stranded RNA viruses and employ a complicated pattern of virus genome length RNA replication as well as transcription of genome length and leader containing subgenomic RNAs. Although not fully understood, both replication and transcription are thought to take place in so-called double-membrane vesicles in the cytoplasm of infected cells. Here we show detection of SARS-CoV-2 subgenomic RNAs in diagnostic samples up to 17 days after initial detection of infection and provide evidence for their nuclease resistance and protection by cellular membranes suggesting that detection of subgenomic RNAs in such samples may not be a suitable indicator of active coronavirus replication/infection. |*Genome, Viral[MESH] |*Virus Replication[MESH] |Adult[MESH] |COVID-19 Testing/*methods[MESH] |COVID-19/*diagnosis/virology[MESH] |Cytoplasm/virology[MESH] |Female[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Nasopharynx/cytology/virology[MESH] |Oropharynx/cytology/virology[MESH] |Polymerase Chain Reaction[MESH] |RNA, Viral/*isolation & purification[MESH] |SARS-CoV-2/*genetics/isolation & purification/pathogenicity[MESH] |Time Factors[MESH]SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not a(epmc).pdf DeepDyve Pubget Overpricing