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10.1016/j.transci.2020.103019

http://scihub22266oqcxt.onion/10.1016/j.transci.2020.103019
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suck abstract from ncbi


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pmid33246837      Transfus+Apher+Sci 2020 ; 59 (6): 103019
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  • Benford s law and metabolomics: A tale of numbers and blood #MMPMID33246837
  • D'Alessandro A
  • Transfus Apher Sci 2020[Dec]; 59 (6): 103019 PMID33246837show ga
  • The Newcomb-Benford law - also known as the "law of anomalous numbers" or, more commonly, Benford's law - predicts that the distribution of the first significant digit of random numbers obtained from mixed probability distributions follows a predictable pattern and reveals some universal behavior. Specifically, given a dataset of empirical measures, the likelihood of the first digit of any number being 1 is approximately 30 %, approximately 18 % for 2, 12.5 % for 3 and so on, with a decreasing probability all the way to number 9. If the digits were distributed uniformly, all the numbers 1 through 9 would have the same probability to appear as the first digit in any given empirical random measurement. However, this is not the case, as this law defies common sense and seems to apply seamlessly to large data. The use of omics technologies and, in particular, metabolomics has generated a wealth of big data in the field of transfusion medicine. In the present meta-analysis, we focused on previous big data from metabolomics studies of relevance to transfusion medicine: one on the quality of stored red blood cells, one on the phenotypes of transfusion recipients, i.e. trauma patients suffering from trauma and hemorrhage, and one of relevance to the 2020 SARS-COV-2 global pandemic. We show that metabolomics data follow a Benford's law distribution, an observation that could be relevant for future application of the "law of anomalous numbers" in the field of quality control processes in transfusion medicine.
  • |*Metabolomics[MESH]
  • |*Pandemics[MESH]
  • |COVID-19/*blood/*epidemiology[MESH]
  • |Humans[MESH]


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