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10.1080/13543776.2021.1857726 http://scihub22266oqcxt.onion/10.1080/13543776.2021.1857726 33246378!ä!33246378 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33246378&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33246378.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Expert+Opin+Ther+Pat 2021 ; 31 (4): 309-324 Nephropedia Template TP {{tp|p=33246378|t=2021. Protease inhibitors targeting the main protease and papain-like protease of coronaviruses |pdf=|usr=}}{{33246378}} gab.com Text Protease inhibitors targeting the main protease and papain-like protease of coronaviruses JO: Expert Opin Ther Pat http://www.kidney.de/pget.php?&tw=1&pmid=33246378 #FOAvip INTRODUCTION: The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (M(pro)) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals. AREAS COVERED: We review the drug design landscape in the scientific and patent literature to design peptidomimetic and non-peptidomimetic protease inhibitors (PIs) targeting these proteins. EXPERT OPINION: The X-ray crystal structures of some of these proteases, alone and in complex with various inhibitors, were crucial for the discovery of effective such compounds, some of which also showed considerable antiviral activity and are considered preclinical candidates to fight these emerging infections, which in the case of Covid-19 already provoked an unprecedented worldwide pandemic. Twit Text FOAVip Protease inhibitors targeting the main protease and papain-like protease of coronaviruses ????Expert Opin Ther Pat http://www.kidney.de/pget.php?&tw=1&pmid=33246378 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33246378 #FOAvip English Wikipedia <ref>{{Cite pmid|33246378}}</ref> Protease inhibitors targeting the main protease and papain-like protease of coronaviruses #MMPMID33246378 Capasso C; Nocentini A; Supuran CT Expert Opin Ther Pat 2021[Apr]; 31 (4): 309-324 PMID33246378show ga INTRODUCTION: The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (M(pro)) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals. AREAS COVERED: We review the drug design landscape in the scientific and patent literature to design peptidomimetic and non-peptidomimetic protease inhibitors (PIs) targeting these proteins. EXPERT OPINION: The X-ray crystal structures of some of these proteases, alone and in complex with various inhibitors, were crucial for the discovery of effective such compounds, some of which also showed considerable antiviral activity and are considered preclinical candidates to fight these emerging infections, which in the case of Covid-19 already provoked an unprecedented worldwide pandemic. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/*pharmacology[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors/chemistry[MESH] |Coronavirus Papain-Like Proteases/*antagonists & inhibitors/chemistry[MESH] |Drug Discovery[MESH] |Humans[MESH] |Protease Inhibitors/*pharmacology[MESH]Protease inhibitors targeting the main protease and papain-like protea(epmc).pdf DeepDyve Pubget Overpricing