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10.1016/j.chom.2020.11.003 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.11.003 33245857!7670925!33245857     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2020 ; 28 (6): 853-866.e5 Nephropedia Template TP {{tp|p=33245857|t=2020. Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies |pdf=|usr=}}{{33245857}} gab.com Text Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33245857 #FOAvip Pathogenesis induced by SARS-CoV-2 is thought to result from both an inflammation-dominated cytokine response and virus-induced cell perturbation causing cell death. Here, we employ an integrative imaging analysis to determine morphological organelle alterations induced in SARS-CoV-2-infected human lung epithelial cells. We report 3D electron microscopy reconstructions of whole cells and subcellular compartments, revealing extensive fragmentation of the Golgi apparatus, alteration of the mitochondrial network and recruitment of peroxisomes to viral replication organelles formed by clusters of double-membrane vesicles (DMVs). These are tethered to the endoplasmic reticulum, providing insights into DMV biogenesis and spatial coordination of SARS-CoV-2 replication. Live cell imaging combined with an infection sensor reveals profound remodeling of cytoskeleton elements. Pharmacological inhibition of their dynamics suppresses SARS-CoV-2 replication. We thus report insights into virus-induced cytopathic effects and provide alongside a comprehensive publicly available repository of 3D datasets of SARS-CoV-2-infected cells for download and smooth online visualization. Twit Text FOAVip Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33245857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33245857 #FOAvip English Wikipedia <ref>{{Cite pmid|33245857}}</ref> Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies #MMPMID33245857 Cortese M; Lee JY; Cerikan B; Neufeldt CJ; Oorschot VMJ; Kohrer S; Hennies J; Schieber NL; Ronchi P; Mizzon G; Romero-Brey I; Santarella-Mellwig R; Schorb M; Boermel M; Mocaer K; Beckwith MS; Templin RM; Gross V; Pape C; Tischer C; Frankish J; Horvat NK; Laketa V; Stanifer M; Boulant S; Ruggieri A; Chatel-Chaix L; Schwab Y; Bartenschlager R Cell Host Microbe 2020[Dec]; 28 (6): 853-866.e5 PMID33245857show ga Pathogenesis induced by SARS-CoV-2 is thought to result from both an inflammation-dominated cytokine response and virus-induced cell perturbation causing cell death. Here, we employ an integrative imaging analysis to determine morphological organelle alterations induced in SARS-CoV-2-infected human lung epithelial cells. We report 3D electron microscopy reconstructions of whole cells and subcellular compartments, revealing extensive fragmentation of the Golgi apparatus, alteration of the mitochondrial network and recruitment of peroxisomes to viral replication organelles formed by clusters of double-membrane vesicles (DMVs). These are tethered to the endoplasmic reticulum, providing insights into DMV biogenesis and spatial coordination of SARS-CoV-2 replication. Live cell imaging combined with an infection sensor reveals profound remodeling of cytoskeleton elements. Pharmacological inhibition of their dynamics suppresses SARS-CoV-2 replication. We thus report insights into virus-induced cytopathic effects and provide alongside a comprehensive publicly available repository of 3D datasets of SARS-CoV-2-infected cells for download and smooth online visualization. |COVID-19/diagnostic imaging/*genetics/pathology/virology[MESH] |Cell Death/genetics[MESH] |Endoplasmic Reticulum/genetics/*ultrastructure/virology[MESH] |Humans[MESH] |Microscopy, Electron[MESH] |Pandemics[MESH] |SARS-CoV-2/genetics/pathogenicity/*ultrastructure[MESH] |Viral Replication Compartments/metabolism/*ultrastructure[MESH]Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellula(epmc).pdf DeepDyve Pubget Overpricing