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10.11604/pamj.2020.37.78.25100

http://scihub22266oqcxt.onion/10.11604/pamj.2020.37.78.25100
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33244341!7680236!33244341
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suck abstract from ncbi


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pmid33244341      Pan+Afr+Med+J 2020 ; 37 (ä): 78
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  • An elevated 8-isoprostaglandin F2 alpha (8-iso-PGF2alpha) in COVID-19 subjects co-infected with malaria #MMPMID33244341
  • Muhammad Y; Aminu YK; Ahmad AE; Iliya S; Muhd N; Yahaya M; Mustapha AS; Tahiru A; Abdulkadir SS; Ibrahim JS; Ahmad AB; Muhammad IY; Shehu Z; Yakubu A; Muhd BK; Ahmed A; Faruk UA
  • Pan Afr Med J 2020[]; 37 (ä): 78 PMID33244341show ga
  • INTRODUCTION: the most recently discovered severe acute respiratory syndrome Coronavirus 2 (SARS-COV-2) that causes COVID-19, subjected the entire world in turmoil health-wise and economically. With higher burden of malaria in Nigeria and other sub-Saharan African countries coupled with fragile healthcare system and delivery, these may pose a threat in the diagnosis and management of COVID-19 patients co-infected with malaria. Free radicals have been implicated in the progression and pathogenesis of malaria and COVID-19 through Fenton's reaction and cytokine storm respectively. METHODS: the current research comprises of seventy-four (74) participants; 20 apparently healthy controls and 54 COVID-19 patients (34 among which were co-infected with malaria). Serum levels of 8-iso PGF2alpha and Alphatocopherol were determined among the study participants using ELISA technique and colorimetric assay, respectively. RESULTS: results revealed statistically significant elevation of 8-iso PGF2alpha in COVID-19 patients co-infected with malaria compared to COVID-19 patients only, and this may be due to increase production of free radicals. Furthermore, a significant decrease of Alphatocopherol was observed in COVID-19 co-infected with malaria compared to COVID-19 patients due to increase utilization of antioxidants in counterbalancing the negative effect of free radicals generated. CONCLUSION: conclusively, SARS-COV-2 patients co-infected with malaria might be predisposed to oxidative stress and low Alphatocopherol. The increase in oxidative stress is proportional to malaria parasite density and inversely related to Alphatocopherol levels. This implies that oxidative stress is notably higher and such patients may have a severer form of the COVID-19. Increased 8-iso-PGF2alpha in co-infection and decreased alphatocopherol levels can reflect the severity and adverse outcomes compared to COVID-19 naive because of their tremendous involvement in the pathogenesis and progression of diseases.
  • |*SARS-CoV-2[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19 Testing/methods[MESH]
  • |COVID-19/*blood[MESH]
  • |Case-Control Studies[MESH]
  • |Coinfection/*blood/diagnosis[MESH]
  • |Colorimetry/methods[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Dinoprost/*analogs & derivatives/blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Malaria/*blood/diagnosis/parasitology[MESH]
  • |Male[MESH]
  • |Nigeria[MESH]
  • |Oxidative Stress[MESH]
  • |Pandemics[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]


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