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10.1038/s41467-020-19808-4 http://scihub22266oqcxt.onion/10.1038/s41467-020-19808-4 33243994!7693302!33243994     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 6013 Nephropedia Template TP {{tp|p=33243994|t=2020. SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity |pdf=|usr=}}{{33243994}} gab.com Text SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33243994 #FOAvip SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (S(G614)) with the original (S(D614)). We report here pseudoviruses carrying S(G614) enter ACE2-expressing cells more efficiently than those with S(D614). This increased entry correlates with less S1-domain shedding and higher S-protein incorporation into the virion. Similar results are obtained with virus-like particles produced with SARS-CoV-2 M, N, E, and S proteins. However, D614G does not alter S-protein binding to ACE2 or neutralization sensitivity of pseudoviruses. Thus, D614G may increase infectivity by assembling more functional S protein into the virion. Twit Text FOAVip SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33243994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33243994 #FOAvip English Wikipedia <ref>{{Cite pmid|33243994}}</ref> SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity #MMPMID33243994 Zhang L; Jackson CB; Mou H; Ojha A; Peng H; Quinlan BD; Rangarajan ES; Pan A; Vanderheiden A; Suthar MS; Li W; Izard T; Rader C; Farzan M; Choe H Nat Commun 2020[Nov]; 11 (1): 6013 PMID33243994show ga SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (S(G614)) with the original (S(D614)). We report here pseudoviruses carrying S(G614) enter ACE2-expressing cells more efficiently than those with S(D614). This increased entry correlates with less S1-domain shedding and higher S-protein incorporation into the virion. Similar results are obtained with virus-like particles produced with SARS-CoV-2 M, N, E, and S proteins. However, D614G does not alter S-protein binding to ACE2 or neutralization sensitivity of pseudoviruses. Thus, D614G may increase infectivity by assembling more functional S protein into the virion. |*Virus Internalization[MESH] |Amino Acid Substitution[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/epidemiology/*virology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Mutation[MESH] |Pandemics[MESH] |SARS-CoV-2/genetics/*pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/*genetics/metabolism[MESH] |Virion/*metabolism[MESH]SARS-CoV-2 spike-protein D614G mutation increases virion spike density(epmc).pdf DeepDyve Pubget Overpricing